Cyproheptadine is a combined serotonin and histamine antagonist used in the treatment of allergic symptoms, for appetite stimulation, and off-label in the treatment of serotonin syndrome.

Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties.

Cyproheptadine is a widely prescribed first-generation antihistamine, and due to its unique chemical structure, it has a popular off-label choice for a range of clinical conditions. Its efficacy is widely debated in the literature, but there are reports of hepatotoxicity as a rare adverse effect.

2020年2月17日 · Includes Cyproheptadine indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more.

2021年10月1日 · Check creatinine kinase and treat rhabdomyolysis if necessary. Most cases are mild-moderate, and will improve in about a day following cessation of medications. However, serotonin syndrome can be severe and may require ICU admission.

2016年9月19日 · Cyproheptadine is an antiserotonin, antihistaminic compound used in adults and children to stimulate weight gain. When given to adult rats in repeated high doses, this chemical produces an inhibition of proinsulin synthesis, a reduction in …

Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome.

2024年7月25日 · H1-receptor & serotonin (5-HT2A) receptor antagonist. Also has anti-muscarinic effects. Goadsby PJ, Raskin NH (2012): Headache (Chapter 15). In: Harrison's Principles of …

Cyproheptadine is a sedative antihistamine with serotonin antagonist, and calcium-channel blocking actions. It competes with Histamine for H1 receptors present in the smooth muscle of gastrointestinal tract, bronchi, large blood vessels and uterus.

Cyproheptadine is a central acting H1 R antagonist reported to be effective in migraine prophylaxis. It has been historically used in pediatric migraineurs because of reported clinical benefits along with mild side effects and an available liquid formulation [105, 106].