Cysteine - Wikipedia
Cysteine residues play a valuable role by crosslinking proteins, which increases the rigidity of proteins and also functions to confer proteolytic resistance (since protein export is a costly process, minimizing its necessity is advantageous).
Functional Diversity of Cysteine Residues in Proteins and Unique ...
Functional categories of cysteine residues. Among the 20 common amino acids in proteins, Cys is one of two least abundant yet the most conserved residue that is frequently present in functionally important sites (i.e., catalytic, regulatory, cofactor binding, etc.) in proteins.
Cysteine Reactivity Across the Sub-Cellular Universe - PMC
The unique functions of cysteine residues found in the mitochondria and endoplasmic reticulum are highlighted, together with an overview into chemoproteomic platforms employed to investigate cysteine reactivity in subcellular organelles.
Cysteine Residue - an overview | ScienceDirect Topics
Cysteine residue is a specific amino acid component in proteins that contains a sulfur atom, making it a valuable target for simplifying protein analysis due to its high representation in human proteins and availability of chemistries for selective targeting.
Cysteine Oxidation in Proteins: Structure, Biophysics, and Simulation
Thiol groups in protein cysteine (Cys) residues can undergo one- and two-electron oxidn. reactions leading to the formation of thiyl radicals or sulfenic acids, resp. In this mini-review we summarize the mechanisms and kinetics of the formation of …
Cysteine function governs its conservation and degeneration and ...
Cysteine (Cys) is an enigmatic amino acid residue. Although one of the least abundant, it often occurs in functional sites of proteins. Whereas free Cys is a polar amino acid, Cys in proteins is often buried and its classification on the hydrophobicity scale is ambiguous.
Analysis and Functional Prediction of Reactive Cysteine Residues
2012年2月2日 · Being one of the least abundant residues, Cys is often observed in functional sites in proteins. This residue is reactive, polarizable, and redox-active; has high affinity for metals; and is particularly responsive to the local environment.
Targeting Non-Catalytic Cysteine Residues Through Structure …
Here, we review three applications of cysteine-modifying small molecules: 1) the optimization of existing drug leads, 2) the discovery of new lead compounds, and 3) the use of cysteine-reactive molecules as probes of protein dynamics.
Computational functional analysis of cysteine residues in proteins ...
2022年1月1日 · Site-specific proteomic mapping identifies selectively modified regulatory cysteine residues in functionally distinct protein networks
Positions of cysteine residues reveal local clusters and hidden ...
2024年10月29日 · The analyzed features included cysteine residues, annotated disulfide bonds, sequons, and predicted transmembrane domains.