CYTOCHROME P450 DRUG INTERACTION TABLE - IU
Clinical Pharmacology School of Medicine. Menu. Home; Main-Table; Search; Pocket-Card; Memoriam; Contact
Drug Interactions, Clinical Pharmacology, Department of Medicine
This table is designed as a teaching and reference tool for health care providers and researchers interested in drug interactions that are mediated by cytochrome P450 enzymes. The table contains lists of drugs in columns under the designation of specific cytochrome P450 isoforms.
3A457 References - Drug Interactions
Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs. [ PMID 3378384 ]
2C19 REFERENCES - Drug Interactions
Cytochrome P450 2C9 catalyzes indomethacin O-demethylation in human liver microsomes. [ PMID 9492390 ] Nakajima M, Inoue T, Shimada N, Tokudome S, Yamamoto T, Kuroiwa Y.
2D6References - Drug Interactions - IU
Comparison of duloxetine, escitalopram, and sertraline effects on cytochrome P450 2D6 function in healthy volunteers. [ PMID 17224709 ] Preskorn SH, Greenblatt DJ, Flockhart D, Luo Y, Perloff ES, Harmatz JS, Baker B, Klick-Davis A, Desta Z, Burt T.
2C9 References - Drug Interactions
Human hepatic Cytochrome P450 catalyses the rate-limiting pathway of torsemide metabolism. [ PMID 7891318 ] Miners JO, Rees DLP, Valente L, Veronese ME, Birkett DJ.
- Drug Interactions - IU
Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: Response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines. [ PMID 9157990 ] Chang TK, Yu L, Maurel P, Waxman DJ
2C8References - Drug Interactions - IU
The xenobiotic inhibitor profile of cytochrome P4502C8. [ PMID 11136296] Ong CE, Coulter S, Birkett DJ, Bhasker CR, Miners JO. Br J Clin Pharmacol. 2000 Dec;50(6):573-80.
Search Drug Interactions Flockhart Table - IU
Search Drug Interactions Flockhart Table ™ Select Filter. Drug Name. Isoform Gene Expression. Type of Interaction Clear. Additional resources. Indiana University. 107 S. Indiana Avenue Bloomington, IN 47405-7000 Clinical Pharmacology. Research Institute (R2), Room 402 950 West Walnut Street ...
2E1 References - Drug Interactions
Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro. [ PMID 9103523 ] Spracklin DK, Hankins DC, Fisher JM, Thummel KE, Kharasch ED.