The DNA-damage response in human biology and disease
2009年10月22日 · To counter this threat, life has evolved several systems to detect DNA damage, signal its presence and mediate its repair. Such responses, which have an impact on a wide range of cellular...
The DNA-damage response in human biology and disease
To combat threats posed by DNA damage, cells have evolved mechanisms – collectively termed the DNA-damage response (DDR) – to detect DNA lesions, signal their presence and promote their repair 10-12.
DNA Damage Response - an overview | ScienceDirect Topics
The DNA damage response (DDR) is an evolutionarily conserved signaling network, activated by DNA damage, which leads to DNA repair, ranging from base excision repair (BER) to homologues recombination (HR) and non-homologues end-joining (NHEJ) repair process.
Mechanisms of DNA damage, repair and mutagenesis - PMC
DNA damage response (DDR) After the DNA is damaged, lesion-specific sensor proteins initiate a DNA damage response. The DDR is a collection of mechanisms that sense DNA damage, signal its presence and promote subsequent repair [Harper and Elledge, 2007].
DNA damage repair: historical perspectives, mechanistic pathways and ...
2021年7月9日 · In this review, we first illustrate the timeline steps for the understanding the roles of DNA damage repair in the promotion of cancer and cancer therapy developed, then we summarize the...
DNA Damage Response: Three Levels of DNA Repair Regulation
Multiple repair enzymes scan the DNA for problems, remove the offending damage, and restore the DNA duplex. These repair mechanisms are regulated by DNA damage response kinases including DNA-PKcs, ATM, and ATR that are activated at DNA lesions.
DNA damage (naturally occurring) - Wikipedia
The DNA damage response (DDR) is a complex signal transduction pathway which recognizes when DNA is damaged and initiates the cellular response to the damage. [2] DNA damage and mutation have different biological consequences. While most DNA damages can undergo DNA repair, such repair is not 100% efficient. Un-repaired DNA damages accumulate in ...
DNA damage response - PMC - National Center for …
2018年2月2日 · The response to DNA damage involves DNA damage recognition first, followed by resection of the affected site, DNA processing, filling the gap by action of DNA polymerases, and sealing of the nick by DNA ligases.
The DNA damage response - from cell biology to human disease
2022年5月12日 · Unrepaired DNA damage can induce cancer-causing mutations, cell death or senescence, and aging. The type of damage leads to distinct phenotypes and the activation of specific repair pathways.
DNA Damage Response - an overview | ScienceDirect Topics
The DNA Damage Response (DDR) is a constellation of cellular pathways that sense, signal and repair DNA lesions after DNA damage to maintain DNA integrity and prevent the generation of potentially detrimental mutations.