Desmin - Wikipedia
Desmin is a protein that in humans is encoded by the DES gene. [5][6] Desmin is a muscle-specific, type III intermediate filament [7] that integrates the sarcolemma, Z disk, and nuclear membrane in sarcomeres and regulates sarcomere architecture. [8][9]
Desmin: a major intermediate filament protein essential for ...
2004年11月15日 · Desmin is a muscle-specific protein and a key subunit of the intermediate filament in cardiac, skeletal and smooth muscles. Desmin filaments are mainly located at the periphery of Z-disk of striated muscles and at the dense bodies of smooth muscle cells, and they have been postulated to play a criti …
Desmin - MyPathologyReport.ca
Desmin is a protein made by muscle cells. Non-cancerous and cancerous tumours made up of muscle cells also produce desmin.
DES Gene - Desmin
2024年10月1日 · DES (Desmin) is a Protein Coding gene. Diseases associated with DES include Myopathy, Myofibrillar, 1 and Scapuloperoneal Syndrome, Neurogenic, Kaeser Type. Among its related pathways are Striated muscle contraction pathway and Cardiac conduction.
DES gene: MedlinePlus Genetics
The DES gene provides instructions for making a protein called desmin. Desmin is found in heart (cardiac) muscle and muscles used for movement (skeletal muscle). Within muscle fibers, desmin proteins are important to help maintain the structure of sarcomeres, which are necessary for muscles to tense (contract).
What does desmin do: A bibliometric assessment of the ...
Intermediate filaments were first described in muscle in 1968, and desmin was biochemically identified about 10 years afterwards. Its importance grew after the identification of desminopathies and desmin mutations that cause mostly cardiopathies. ...
Desmin variants: Trigger for cardiac arrhythmias? - PMC
2022年9月9日 · Genetic variations and loss of desmin drive a variety of conditions, so-called desminopathies, which include desmin-related cardiomyopathy, conduction system-related atrial and ventricular arrhythmias, and sudden cardiac death.