2021年11月17日 · DORAs are insomnia medications that reduce wakefulness. Research suggests they may help people fall asleep and stay asleep, but more studies are needed.

2024年2月1日 · Dual orexin receptor antagonists (DORAs) are a newer class of insomnia medications. They work by blocking signals in the brain that stimulate wakefulness. DORAs may offer an alternative to...

2022年11月28日 · Now, people with insomnia, they’re working overtime. The dual orexin receptor antagonists block those receptors in the brain and help someone fall asleep and remain asleep. It’s very different than knocking someone over the head with a sledgehammer with a Z-drug or a benzodiazepine.

2023年4月4日 · Dayvigo (lemborexant) is classified as a dual orexin receptor antagonist (DORA). It is approved for the treatment of adults with insomnia who have trouble falling asleep or staying asleep. Dayvigo works by blocking the wake-promoting neuropeptides orexin A and orexin B from attaching to their receptors in the hypothalamus of the brain.

Daridorexant, which belongs to the dual orexin receptor antagonist (DORA) drug class, has been shown to help induce sleep and maintain longer periods of sleep, resulting in improved daytime performance and function.

2017年11月15日 · Lemborexant (E2006) is an orally active investigational DORA in clinical development. Presented here are the results from a phase 2 study of the efficacy and safety of lemborexant in the treatment of subjects with insomnia disorder. The study used a Bayesian adaptive design to permit more efficient use of the data.

2021年12月2日 · One of the new types of medications your doctor may suggest for insomnia is dual orexin receptor antagonists (DORAs). These new prescription sleep medications work by blocking orexin, a...

2022年12月1日 · Advanced practice practitioners discuss dual orexin receptor antagonists (DORAs) suvorexant, lemborexant, and daridorexant for the treatment of sleep disorders. EP: 1. Insomnia in Clinical Practice. EP: 2. Common Sleep Disorders and Their Impact on Quality of Life. EP: 3. The Co-occurrence of Sleep Disorders with Other Health Conditions. EP: 4.

When using a DORA, dosing may play an important role in sleep maintenance, and higher doses correlate with longer TSTs for each individual drug. Additional trials comparing two or more DORAs are needed.

There are currently four approved categories of medications: DORAs, BZRAs, histamine receptor antagonists, and melatonin receptor agonists. Daridorexant is a DORA that was recently approved by the US FDA for the treatment of adults suffering from insomnia.