The epidermal growth factor receptor variant III (EGFRvIII ... - PubMed
Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant …
EGFRvIII: An Oncogene with Ambiguous Role - PMC - PubMed …
EGFRvIII increases mismatch repair protein expression and is therefore a predictive marker for temozolomide response in O6-methylguanine-DNA methyltransferase negative glioblastoma cells and tumors. Neuro-Oncology. 2016;18(suppl_6):p. vi208. doi: 10.1093/neuonc/now212.879.
Current Therapeutic Advances Targeting EGFR and EGFRvIII in ...
Epidermal growth factor receptor (EGFR) and EGFRvIII analysis is of current interest in glioblastoma – the most common malignant primary CNS tumor, because of new EGFRvIII vaccine trials underway.
EGFR Phosphorylates Tumor-Derived EGFRvIII Driving STAT3/5 …
Oct 14, 2013 · We document coexpression of EGFR and EGFRvIII in human tumors, identify a cell-intrinsic role for coexpression in vitro and in vivo, and demonstrate that EGFR and EGFRvIII cooperate to phosphorylate STAT proteins, promoting malignant progression.
The epidermal growth factor receptor variant type III mutation ...
The epidermal growth factor receptor variant type III (EGFRvIII) is the most common mutation of EGFR in glioblastoma multiforme (GBM) and is found in approximately 25% of all GBMs. Intriguingly, EGFRvIII is mostly found in GFAP + astrocytic tumour cells in the brain, suggesting connection of EGFRvIII to astrogenesis.
EGFRvIII: the promiscuous mutation - PMC - National Center for ...
Jul 4, 2016 · EGFRvIII is known to contain a free cysteine that is not present in untruncated EGFR, and we have shown that this cysteine is critical for the activation of EGFRvIII and for its ability to transactivate other receptor tyrosine kinases such as c-Met. 6 Uncovering the role of this cysteine in the EGFRvIII–OSMR complex may provide new ...
Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in
Nov 14, 2017 · Purpose: Approximately 40% of all glioblastomas have amplified the EGFR gene, and about half of these tumors express the EGFRvIII variant.
Jun 21, 2024 · To shed light on the role of EGFRvIII and its potential as a therapeutic target, we determined X-ray crystal structures of a monomeric EGFRvIII extracellular region (ECR). The EGFRvIII ECR resembles the unliganded conformation of EGFR, including the orientation of the C-terminal region of domain II.
Intragenic EGFR::EGFR .E1E8 Fusion (EGFRvIII) in 4331 Solid Tumors
Dec 19, 2023 · Epidermal growth factor receptor variant III (EGFRvIII) is caused by the deletion of six exons and the fusion of exons 1 to exon 8. EGFRvIII occurs frequently in glioblastoma, a type of high-grade brain tumor; however, its presence in other solid tumors is not well characterized.
EGFR mutations and abnormal trafficking in cancers
Aug 21, 2024 · EGFRvIII is a mutated form of EGFR, that is found in 40–50% of EGFR-amplified glioblastomas. It arises from the deletion of exons 2–7, resulting in the absence of the extracellular ligand-binding domain and constitutive activity [ 57 ].