Estrogen receptor - Wikipedia
Estrogen receptors (ERs) are proteins found in cells that function as receptors for the hormone estrogen (17β-estradiol). [1] There are two main classes of ERs. The first includes the intracellular estrogen receptors, namely ERα and ERβ, which belong to the nuclear receptor family.
Breast Cancer Hormone Receptor Status | Estrogen Receptor
2021年5月11日 · Hormone receptor-positive (or hormone-positive) breast cancer cells have either estrogen (ER) or progesterone (PR) receptors or both. These breast cancers can be treated with hormone therapy drugs that lower estrogen levels or block estrogen receptors.
The Estrogen Receptors: An Overview from Different …
The estrogen receptors, ERα, ERβ, and GPER, mediate the effects of estrogenic compounds on their target tissues. Estrogen receptors are located in the tissues of the female reproductive tract and breast as one would expect, but also in tissues …
Estrogen Hormone Biology - PMC - PubMed Central (PMC)
Estrogen works through its two distinct nuclear receptors, Estrogen Receptor alpha (ERα) and Estrogen Receptor beta (ERβ).
Roles of Estrogen, Estrogen Receptors, and Estrogen-Related Receptors …
Estrogen regulates the expression of its target genes by binding to its cognate receptors, estrogen receptors (ERs) α and β. Notably, the estrogen-related receptors (ERRs) α, β, and γ are originally identified as orphan receptors that share substantial structural homology and common transcriptional targets with ERs.
Estrogen Receptors: How Do They Signal and What Are Their …
In this review we focus on several of the interesting recent discoveries concerning estrogen receptors, on estrogen as a morphogen, and on the molecular mechanisms of anti-estrogen signaling. Estrogens play key roles in development and maintenance of normal sexual and reproductive function.
Estrogen receptor signaling mechanisms - PubMed
Estrogens exert their actions by binding to specific receptors, the estrogen receptors (ERs), which in turn activate transcriptional processes and/or signaling events that result in the control of gene expression.
Estrogen Receptor Status and Breast Cancer Prognosis - Susan …
2024年10月4日 · People with estrogen receptor-positive early breast cancers tend to have better survival than people with estrogen receptor-negative early breast cancers [1]. As the studies below show, 5-year survival after diagnosis is about 10% better for women with estrogen receptor-positive early breast cancer than for those with estrogen receptor-negative ...
Estrogen Receptors: New Directions in the New Millennium
In this review we discuss the basic understanding of estrogen signaling and then elaborate on the progress and current understanding of estrogen receptor actions that have developed using new models and continuing clinical studies.
Hormone receptor - Wikipedia
A hormone receptor is a receptor molecule that binds to a specific hormone. Hormone receptors are a wide family of proteins made up of receptors for thyroid and steroid hormones, retinoids and Vitamin D, and a variety of other receptors for various ligands, such as fatty acids and prostaglandins. [1]