Fas ligand (FASL or CD95L) is a type-II transmembrane protein expressed on various types of cells, including cytotoxic T lymphocytes, monocytes, neutrophils, breast epithelial cells, vascular endothelial cells and natural killer (NK) cells.

FAS (also known as APO-1 or CD95) belongs to the subgroup of the tumor necrosis factor receptor (TNF-R) family that contain an intra-cellular ‘death domain’ and can trigger apoptosis. Its physiological ligand, FASL (CD95L), is a member of the ...

The Fas receptor is a death receptor on the surface of cells that leads to programmed cell death (apoptosis) if it binds its ligand, Fas ligand (FasL). It is one of two apoptosis pathways, the other being the mitochondrial pathway.

Nakayama M, Nagata M, Yasuda H, Arisawa K, Kotani R, Yamada K, et al. Fas/Fas ligand interactions play an essential role in the initiation of murine autoimmune diabetes.

Fas Ligand is a type I integral membrane protein that is structurally related to TNFR1. It is an essential component in the induction of cell death by cytotoxic T cells (CTLs) and natural killer (NK) cells.

2016年9月26日 · Fas and Fas Ligand (FasL) are members of the tumor necrosis factor (TNF)-receptor and TNF family, respectively. The ligation of Fas with FasL results in the activation of a caspase cascade that initiates apoptosis (1 – 5).

2006年3月15日 · Fas ligand (FasL), a member of the TNF protein family, potently induces cell death by activating its matching receptor Fas. Fas-mediated killing plays a critical role in naturally and pathologically occurring cell death, including development and …

Expression of ligand in a functionally active form is highly regulated at the transcriptional level as well as by cleavage by metalloproteinases. Since Fas/Fas ligand delete activated cells in the peripheral immune system, defects in this pathway predispose to autoimmune disorders.

The ligand for the Fas receptor (FasL) is a trimeric type 2 membrane protein that closely resembles other TNF-like molecules and can be released in soluble form after cleavage from the membrane...

2014年1月1日 · Fas and Fas ligand (Fasl) are transmembrane proteins that belong to the TNF receptor family and TNF family of proteins, respectively. Fas (CD95) is expressed on many types of cells, yielding them susceptible of killing by cells expressing Fasl.