Type-I collagen produced by distinct fibroblast lineages reveals ...
Dec 10, 2021 · Here, the authors show that different classes of fibroblasts produce collagen of unique functions with different impacts on embryo development and bone formation. Type I collagen (Col1) is...
Fibroblast - Wikipedia
A fibroblast is a type of biological cell typically with a spindle shape [1] that synthesizes the extracellular matrix and collagen, [2] produces the structural framework for animal tissues, and plays a critical role in wound healing. [3] Fibroblasts are the most common cells of connective tissue in animals.
Collagen I and the fibroblast: High protein expression requires a …
This review focuses on fibroblasts that make high levels of procollagen (type I) and how they regulate the collagen pathway. Data from many different labs are relevant to this problem but it is hard to see the bigger picture from a large number of small studies.
Histology, Fibroblast - StatPearls - NCBI Bookshelf
May 1, 2023 · In homeostasis, the primary collagen type produced by the fibroblast is organ dependent. Type I is predominant in the skin, I and III are prevalent in the interstitium of the lung, liver, and kidney, and IV collagen is abundant in the alveolar basement membrane.
Fibroblasts and Their Transformations: The Connective-Tissue …
Fibroblasts seem to be the least specialized cells in the connective-tissue family. They are dispersed in connective tissue throughout the body, where they secrete a nonrigid extracellular matrix that is rich in type I and/or type III collagen, as discussed in Chapter 19.
Identification, discrimination and heterogeneity of fibroblasts
Jun 14, 2022 · It is well-established that fibroblasts produce collagens and numerous other proteins that make up the ECM of fibrous connective tissues. In fact, one of the fibroblasts’ archetypical products,...
Fibroblasts: Origins, definitions, and functions in health and disease
Jul 22, 2021 · The major role of the perimysium in force transduction and its distinct ECM are supported by specialized perimysial fibroblasts that express high levels of thrombospondins 1 and 4 and type XI collagen. Perimysial fibroblasts express a number of matrisome and non-matrisome genes shared with tendon and cartilage and, on scRNA-seq, display ...
The bright side of fibroblasts: molecular signature and regenerative ...
Aug 10, 2021 · Dysregulation of any of these processes can trigger excessive ECM deposition, typically rich in collagen I, resulting in the formation of scar tissue—a process that is widely known as fibrosis....
Type I collagen synthesis in cultured human fibroblasts ... - PubMed
Type I collagen synthesis by fibroblasts cultured in three-dimensional collagen gels was strongly down-regulated at both the protein and RNA levels. In addition to its capacity to stimulate collagen synthesis, PDGF-BB induced elongation and the formation of long processes by fibroblasts cultured in collagen gels.
Distinctive roles of fibrillar collagen I and collagen III in mediating ...
Jun 30, 2021 · Collagen I and collagen III have distinctive roles in fibroblast activation. Unidirectionally aligned collagen nano-fibrils prompted cell polarization. The stiffer COLI fibrils exert a higher force to cells. α1β1-integrin binds stronger to COLIII than to COLI. COLI-COLIII hybrid fibrils promoted collagen synthesis the most effectively.