Histone Deacetylase - an overview | ScienceDirect Topics
Histone deacetylases (HDACs) are a group of enzymes that remove acetyl groups from histones, resulting in chromatin condensation and transcriptional repression. They also regulate the acetylation status of non-histone proteins and cytoplasmic proteins. Inhibiting HDACs can lead to hyper-acetylated histones, cell cycle arrest, and cell death.
HDACs, histone deacetylation and gene transcription: from
2007年2月27日 · Histone deacetylases (HDACs) and histone acetyl transferases (HATs) are two counteracting enzyme families whose enzymatic activity controls the acetylation state of protein lysine residues,...
A short guide to histone deacetylases including recent progress …
2020年2月19日 · In this review, current knowledge of HDACs is briefly described with an emphasis on recent progress in research on HDACs, especially on class IIa HDACs. Long eukaryotic DNA is wrapped around...
The role of HDAC3 and its inhibitors in regulation of oxidative …
2023年4月18日 · HDAC3 is critical for early embryonic growth, development of vital organs, and numerous metabolic processes. HDAC3 is closely correlated to mitochondria function and metabolism, ROS-produced...
The many roles of histone deacetylases in development and physiology ...
Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes, largely through their repressive influence on transcription. The expression of many HDAC isoforms in eukaryotic cells raises ...
Metabolism, HDACs, and HDAC Inhibitors: A Systems Biology …
HDAC inhibitors are being explored for treating cancers, viral infections, inflammation, neurodegenerative diseases, and metabolic disorders. However, how HDAC inhibitors impact cellular metabolism and how metabolism influences their potency is unclear.
Histone Deacetylases (HDACs): Evolution, Specificity, Role in
2020年5月15日 · Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles.
Histone Deacetylases: Molecular Mechanisms and Therapeutic
2023年2月21日 · Histone deacetylases (HDACs) are enzymes that regulate the deacetylation of numerous histone and non-histone proteins, thereby affecting a wide range of cellular processes. Deregulation of HDAC expression or activity is often associated with several pathologies, suggesting potential for targeting these enzymes for therapeutic purposes.
Histone Deacetylase - an overview | ScienceDirect Topics
Histone deacetylases (HDAC) are enzymes that remove the acetyl groups from the lysine residues of histones and nonhistone substrates. HDACs regulate tumorigenesis by repressing expression of tumor suppressor genes or regulating oncogenic signaling.
HDAC and HDAC Inhibitor: From Cancer to Cardiovascular Diseases
Histone deacetylases (HDACs) are epigenetic regulators that regulate the histone tail, chromatin conformation, protein-DNA interaction, and even transcription. HDACs are also post-transcriptional modifiers that regulate the protein acetylation implicated in several pathophysiologic states.
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