Haplotype block - Wikipedia
In genetics, a haplotype block is a region of an organism's genome in which there is little evidence of a history of genetic recombination, and which contain only a small number of distinct haplotypes. [1]
On the origin and structure of haplotype blocks - PMC
We highlight a number of novel methods for inferring haplotype structure, based on the full ARG, or on a sequence of trees, and illustrate how they can be used to define haplotype blocks using an empirical data set.
Haplotype blocks and linkage disequilibrium in the human …
2003年8月1日 · Recent studies have proposed that patterns of LD in the human genome can be summarized by a series of discrete haplotype blocks: regions of high LD that are separated from other haplotype...
The Structure of Haplotype Blocks in the Human Genome
2002年5月23日 · We show that the human genome can be parsed objectively into haplotype blocks: sizable regions over which there is little evidence for historical recombination and within which only a few common haplotypes are observed. The boundaries of blocks and specific haplotypes they contain are highly correlated across populations.
Haplotype - Wikipedia
A haplotype (haploid genotype) is a group of alleles in an organism that are inherited together from a single parent. [ 1 ] [ 2 ] Many organisms contain genetic material ( DNA ) which is inherited from two parents.
The structure of haplotype blocks in the human genome
2002年6月21日 · We show that the human genome can be parsed objectively into haplotype blocks: sizable regions over which there is little evidence for historical recombination and within which only a few common haplotypes are observed.
On the origin and structure of haplotype blocks - PubMed
The term "haplotype block" is commonly used in the developing field of haplotype-based inference methods. We argue that the term should be defined based on the structure of the Ancestral Recombination Graph (ARG), which contains complete information on the ancestry of a sample.
We characterized haplotype patterns across 51 autosomal regions (spanning 13Mb of the human genome) in samples from Africa, Europe and Asia.
Haplotype block definition and its application - PubMed
We present a simple two-stage procedure to define haplotype blocks and construct a statistic to test whether a polymorphism belongs to a block. Applying this method to the data of Gabriel et al. [2002] yielded longer haplotype blocks than were originally reported with a similar average percentage of …
Haplotype Block Structure and Its Applications to Association Studies ...
Haplotype blocks, together with the corresponding tag SNPs and common haplotypes determined by haplotype block–partitioning algorithms, can be used in genomewide association studies, as well as in the fine-scale mapping of complex disease genes.
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