Adult Heparin Drip Protocol This protocol reflects current evidence based clinical practice. It is not a substitute for appropriate clinical evaluation and does not supersede clinical judgment. Initiating Heparin therapy: →Extreme Caution: Do not start in patients who have had tPA, for ischemic stroke, within 24 hours. 1.
Heparin is a glycosaminoglycan which inhibits the mechanism that induces the clotting of blood and the formation of stable fibrin clots. It combines with antithrombin III (AT III) and blocks thrombosis by inactivating activated factor X and ultimately inhibiting prothrombin’s (factor II) conversion to thrombin (activated factor II).
I. UNMH nursing-driven UFH protocols are outlined in Table 1. Rapid anticoagulation in patients with acute thrombotic event. II. III. A. Binds to and potentiates antithrombin III which inactivates thrombin (factor IIa) as well as factors IXa, Xa, XIa and XIIa.
Guide to Anticoagulant Therapy: Heparin | Circulation
2001年6月19日 · The 2 preferred routes of administration of unfractionated heparin (UFH) are continuous intravenous (IV) infusion and subcutaneous (SC) injection.
This protocol was updated in June 2009 to include dosage adjustments based on the results of a heparin assay test. Population: Adult patients requiring IV unfractionated heparin anticoagulation therapy.
unfractionated heparin infusion can be recommenced postoperatively. General guidance is: Patients with a very high risk of thromboembolism (i.e. patients with a prosthetic heart valve): recommence the intravenous unfractionated heparin infusion (without bolus) 6 to 8 hours postoperatively. For patients with a high bleeding risk:
the heparin line for a Partial thromboplastin time (PTT) specimen draw, then stop the heparin, flush the line, and aspirate 10 ml of blood to waste prior to drawing a specimen.
• Use a heparin infusion of 1,000 units/ml. No need to dilute – use. heparin 20,000 units in 20ml ampoules. Adjust heparin infusion as follows. Reviewed and supported by the NHS Tayside Multidisciplinary Anticoagulant Liaison Committee.
1) turn off heparin infusion. 2) Repeat STAT Anti-Xa immediately using peripheral blood draw. 3) If repeat Anti-Xa < 1 units/mL, resume heparin according to heparin algorithm.
When an oral anticoagulant (warfarin, oral factor Xa inhibitor or direct-acting anticoagulant) is to be begun in patients already receiving heparin sodium, baseline and subsequent tests of prothrombin activity must be determined at a time when heparin activity is too low to affect the prothrombin time.
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