Hypofrontality - Wikipedia
Hypofrontality is a state of decreased cerebral blood flow (CBF) in the prefrontal cortex of the brain. Hypofrontality is symptomatic of several neurological medical conditions, such as schizophrenia, attention deficit hyperactivity disorder (ADHD), bipolar disorder, and major depressive disorder.
Hypofrontality in schizophrenia: a meta-analysis of functional …
Meta-analysis supports resting hypofrontality in schizophrenia. Task-activated hypofrontality is also supported, but there is little from voxel-based studies to suggest that this is associated with an altered pattern of regional functional architecture.
Hypofrontality in schizophrenia: distributed dysfunctional circuits in ...
1997年6月14日 · The concept of hypofrontality raises important questions about the fundamental nature of schizophrenia—its neural substrates, its course, and its treatment. Do specific regions of the prefrontal cortex have abnormal metabolism or blood flow?
Hypofrontality in Schizophrenia: A Review of the Evidence
This paper reviews the possible role of frontal lobe dysfunction in the pathophysiology of schizophrenia. Pathological, computerized axial tomography (CAT) scan and magnetic resonance imaging (MRI)...
Functional Hypofrontality and Working Memory Dysfunction in Schizophrenia
1998年9月1日 · It is our view that relating neurophysiological mechanisms to cognitive processes is essential to understanding the pathophysiology of schizophrenia. We tested the reliability of hypofrontality in schizophrenia by examining cortical activation associated with increasing working memory demands.
Beyond hypofrontality: A quantitative meta‐analysis of functional ...
2005年4月21日 · We utilize a quantitative meta‐analysis method to review 12 imaging studies where patients with schizophrenia were contrasted with healthy comparison subjects while performing the n‐back paradigm.
Negative symptoms and hypofrontality in chronic schizophrenia
We measured the relationship between decreased relative prefrontal cortex glucose metabolism (hypofrontality) using positron emission tomography and evaluated the severity of negative symptoms in 20 chronic schizophrenics who underwent scanning …
Neuroimaging in schizophrenia: A review article - Frontiers
2022年11月14日 · Many researchers have noticed “hypofrontality” in fluorodeoxyglucose positron emission tomography (FDG PET) investigations of schizophrenia, which implies a decreased frontal to occipital lobe metabolic ratio of FDG utilization (Farkas et al., 1984; Wolkin et al., 1985).
Modelling prefrontal cortex deficits in schizophrenia: implications …
2008年3月3日 · There is a large body of evidence implicating deficits in prefrontal cortex function in schizophrenia. Functional neuroimaging studies show that patients exhibit reduced glucose utilization and blood flow in the prefrontal cortex (hypofrontality).
[Hypofrontality and negative symptoms in schizophrenia: …
Based on a review of a hundred papers, the present article analyses the anatomical and neuropsychological evidence of disturbed frontal lobe functioning in patients with negative schizophrenic symptoms.