Hypofrontality - Wikipedia
Hypofrontality is a state of decreased cerebral blood flow (CBF) in the prefrontal cortex of the brain. Hypofrontality is symptomatic of several neurological medical conditions, such as …
Hypofrontality in schizophrenia: a meta-analysis of functional …
Meta-analysis supports resting hypofrontality in schizophrenia. Task-activated hypofrontality is also supported, but there is little from voxel-based studies to suggest that this is associated …
Hypofrontality in schizophrenia: distributed dysfunctional circuits in ...
Jun 14, 1997 · The concept of hypofrontality raises important questions about the fundamental nature of schizophrenia—its neural substrates, its course, and its treatment. Do specific …
Hypofrontality in Schizophrenia: A Review of the Evidence
This paper reviews the possible role of frontal lobe dysfunction in the pathophysiology of schizophrenia. Pathological, computerized axial tomography (CAT) scan and magnetic …
Functional Hypofrontality and Working Memory Dysfunction in Schizophrenia
Sep 1, 1998 · It is our view that relating neurophysiological mechanisms to cognitive processes is essential to understanding the pathophysiology of schizophrenia. We tested the reliability of …
Beyond hypofrontality: A quantitative meta‐analysis of functional ...
Apr 21, 2005 · We utilize a quantitative meta‐analysis method to review 12 imaging studies where patients with schizophrenia were contrasted with healthy comparison subjects while …
Negative symptoms and hypofrontality in chronic schizophrenia
We measured the relationship between decreased relative prefrontal cortex glucose metabolism (hypofrontality) using positron emission tomography and evaluated the severity of negative …
Neuroimaging in schizophrenia: A review article - Frontiers
Nov 14, 2022 · Many researchers have noticed “hypofrontality” in fluorodeoxyglucose positron emission tomography (FDG PET) investigations of schizophrenia, which implies a decreased …
Modelling prefrontal cortex deficits in schizophrenia: implications …
Mar 3, 2008 · There is a large body of evidence implicating deficits in prefrontal cortex function in schizophrenia. Functional neuroimaging studies show that patients exhibit reduced glucose …
[Hypofrontality and negative symptoms in schizophrenia: …
Based on a review of a hundred papers, the present article analyses the anatomical and neuropsychological evidence of disturbed frontal lobe functioning in patients with negative …