2005年5月1日 · IFN-γ, the only type II IFN, initiates signalling by binding a distinct receptor at the cell surface. Type I and type II IFNs activate both common and distinct STAT (signal transducer and...

Schematic diagram shows major signaling pathways stimulated by IFN-α/β (mediated by the type I IFN receptor) and viral pathogen-associated molecular patterns (PAMPs) and/or ICs-containing nucleic acids (mediated by endosomal TLRs).

Interferons (IFN s, / ˌɪntərˈfɪərɒn / IN-tər-FEER-on[1]) are a group of signaling proteins [2] made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses.

Signalling by the IFNγ receptor activates the Janus kinase (JAK)-signal transducer and activator of transcription 1 (STAT1) pathway to induce the expression of classical interferon-stimulated genes that have key immune effector functions.

Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the development of innate and adaptive immune responses. Canonical type I IFN signalling activates the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway, leading to transcription of IFN-stimulated genes (ISGs).

2013年12月23日 · Type I interferon (IFN) responses are regulated by host, pathogen and environmental factors. These factors calibrate the host defences while limiting tissue damage and preventing autoimmunity.

The interferon (IFN) pathway plays a critical role in the human immune response. Following viral infection, the human body triggers a complex regulatory system of innate and adaptive immune responses designed to defend against the virus.

2021年6月9日 · Get an overview of the canonical and non-canonical interferon signaling pathways involved in the host antiviral response with our interactive pathway poster. Interferons (IFNs) are potent cytokines and key components in the first line of defense against viral infections 1.

2003年8月26日 · The interferon-gamma (IFN-γ) signal transduction pathway closely resembles the canonical Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway.

Type I Interferons (IFN-I) mediate numerous immune interactions during viral infections, from the establishment of an antiviral state to invoking and regulating innate and adaptive immune cells that eliminate infection.