In organic chemistry, indoxyl is a nitrogenous substance with the chemical formula: C 8 H 7 NO. [1][2] Indoxyl is isomeric with oxindol and is obtained as an oily liquid. Indoxyl is obtained from …

Indoxyl sulfate, also known as 3-indoxylsulfate and 3-indoxylsulfuric acid, is a metabolite of dietary L -tryptophan that acts as a cardiotoxin and uremic toxin. [1][2][3] High concentrations of …

2016年11月30日 · Indoxyl sulfate has been most frequently implicated as a contributor to renal disease progression and vascular disease. Studies have suggested that indoxyl sulfate also …

Indoxyl sulfate is one of the most extensively studied solutes that accumulates in the plasma when the kidneys fail. Originally called “indican,” it was first isolated by Obermayer and Popper …

Indoxyl sulfate (IS), a uremic toxin, causes chronic kidney disease (CKD) progression via its tubulotoxicity. After cellular uptake, IS directly induces apoptotic and necrotic cell death of …

2023年5月16日 · Indoxyl sulfate is a protein-bound uremic toxin synthesized from indole that cannot be efficiently removed by the hemodialysis method and thus becomes a key risk factor …

2021年10月25日 · Indoxyl sulfate (IS), results from the sulfonation of bacterially-derived indole via sulfotransferases in human liver 16; however, the rate of indoxyl sulfate production is driven by …

The authors used mouse and zebrafish models to show that circulating indoxyl sulfate (IS) blocked endothelial Wnt signaling, which impaired angiogenesis. Plasma levels of IS and other …

Indoxyl sulfate is an aryl sulfate that is indoxyl in which the hydroxyl hydrogen is substituted by a sulfo group. It has a role as a human metabolite. It is a member of indoles and an aryl sulfate. …

2010年9月15日 · Binds water, Ca (2+), Na (+), K (+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood …