Spinal Inhibitory Interneurons: Gatekeepers of Sensorimotor …
In this review, we provide an overview of identified neural components that make up inhibitory microcircuits within the dorsal and ventral spinal cord and highlight the importance of inhibitory …
Spinal Cord Injury and Loss of Cortical Inhibition - PMC
In summary, a complex clinical scenario reveals that the loss of inhibition following SCI can be helpful on one side to intensify the output signal of cortical motor neurons to the spinal cord. …
Two inhibitory neuronal classes govern acquisition and recall of spinal ...
2024年4月11日 · These findings identify a circuit basis involving two distinct populations of spinal inhibitory neurons, which enables lasting sensorimotor adaptation independently from the …
Central Nervous System Targets: Inhibitory Interneurons in the Spinal Cord
Inhibitory interneurons in the spinal cord can generate two distinct forms of synaptic inhibition mediated through the release of GABA and/or glycine and activation of ligand-gated ion …
Recent advances on signaling pathways and their inhibitors in spinal ...
2024年7月1日 · Spinal cord injury (SCI) is a serious and disabling central nervous system injury. Its complex pathological mechanism can lead to sensory and motor dysfunction. It has been …
Inhibition of the Nogo-pathway in experimental spinal cord …
2023年12月21日 · Recovery after spinal cord injury (SCI) may be propagated by plasticity-enhancing treatments. The myelin-associated nerve outgrowth inhibitor Nogo-A (Reticulon 4, …
Neurotransmitter phenotype switching by spinal excitatory …
2022年5月6日 · In this study, we found that adult spinal cord injury prompts neurotransmitter switching of spatially defined excitatory interneurons to an inhibitory phenotype, promoting …
Salidroside promotes the repair of spinal cord injury by inhibiting ...
2024年5月9日 · Salidroside effectively ameliorated this inhibition of NSCs proliferation through diminishing c-Jun N-terminal kinase (JNK) pathway phosphorylation and restored their …
Inhibition of the Nogo-pathway in experimental spinal cord …
2023年12月21日 · Recovery after spinal cord injury (SCI) may be propagated by plasticity-enhancing treatments. The myelin-associated nerve outgrowth inhibitor Nogo-A (Reticulon 4, …
P2Y6R Inhibition Induces Microglial M2 Polarization by ... - Springer
5 天之前 · As such, we hypothesize that post-spinal cord injury inhibition of P2Y6R may lead to a diminution in microglial cell activation, a suppression of the inflammation, and, subsequently, …