- JunB is a member of the AP-1 (activator protein-1) family of dimeric transcription factors. It exerts a dual action on the cell cycle. It is best known as a cell proliferation inhibitor, a senescence inducer and a tumour suppressor.Author: Marc Piechaczyk, Rosa FarràsPublish Year: 2008pubmed.ncbi.nlm.nih.gov/18793152/
JUNB Gene - GeneCards | JUNB Protein | JUNB Antibody
Dec 25, 2024 · JUNB (JunB Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUNB include Anaplastic Large Cell Lymphoma and Lymphoma. Among its related pathways are IL-1 …
JUNB - Wikipedia
Transcription factor jun-B is a protein that, in humans, is encoded by the JUNB gene. Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.
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JunB: a paradigm for Jun family in immune response and cancer
Sep 3, 2023 · JunB induced by constitutive CD30-extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic large cell …
JUNB JunB proto-oncogene, AP-1 transcription factor subunit
JunB is a key regulator of multiple myeloma bone marrow angiogenesis. Skp2 promotes APL progression through the stabilization of oncoprotein PML-RARalpha and the inhibition of JunB …
JUNB JunB proto-oncogene, AP-1 transcription factor subunit …
The activator protein-1 complex governs a vascular degenerative transcriptional programme in smooth muscle cells to trigger aortic dissection and rupture. AP-1 signaling modulates cardiac …
UniProt
Binds to the DNA sequence 5'-TGA [GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 …
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JunB is a key regulator of multiple myeloma bone …
The present study shows a statistically significant correlation of the AP-1 family member JunB with VEGF, VEGFB, and IGF1 expression levels in MM. In contrast to the angiogenic master regulator Hif-1α, JunB protein levels were …
JunB: a paradigm for Jun family in immune response and cancer
Sep 4, 2023 · This review summarizes the physiological function of JunB, its immune regulatory function, and its contribution to tumorigenesis, especially focusing on its regulatory …
JunB is required for endothelial cell morphogenesis by regulating …
We demonstrate that cell-autonomous endothelial functions of the AP-1 subunit JunB are required for proper endothelial morphogenesis both in vivo in mouse embryos with endothelial-specific …
Regulation and function of JunB in cell proliferation - PubMed
JunB is a member of the AP-1 (activator protein-1) family of dimeric transcription factors. It exerts a dual action on the cell cycle. It is best known as a cell proliferation inhibitor, a senescence …
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