Keratinocyte growth factor - Wikipedia
The keratinocyte growth factor (KGF), also known as FGF7, is a growth factor present in the epithelialization-phase of wound healing. In this phase, keratinocytes are covering the wound, forming the epithelium. KGF is a small signaling molecule that binds to fibroblast growth factor receptor 2b (FGFR2b). [1]
The Roles of Growth Factors in Keratinocyte Migration - PMC
Almost immediately after wounding, cells present at or attracted to the wound site begin to secrete a complex milieu of growth factors. These growth factors exert mitogenic and motogenic effects on KCs, inducing the rapid proliferation and migration of KCs at the wound edge.
An overview on keratinocyte growth factor: from the molecular ... - PubMed
KGF (Keratinocyte Growth Factor), also known as FGF7, is a potent mitogen for different types of epithelial cells, which regulates migration and differentiation of these cells and protects them from various insults under stress conditions.
Keratinocyte growth factor in focus: A comprehensive review …
2021年11月30日 · Keratinocyte growth factor (KGF) protein is an epithelial mitogen and the seventh member of the fibroblast growth factor (FGF) family. The FGF family contains 22 members in vertebrates which are essential for the regulation of …
Keratinocyte Growth Factor - an overview | ScienceDirect Topics
Keratinocyte growth factor (KGF); also designated fibroblast growth factor-7 (FGF-7) is a potent relatively specific growth factor for epithelial cells produced primarily by fibroblasts. FGF-7 is very similar in its action to FGF-10, which is also referred to as KGF-2.
Keratinocyte growth factor - PubMed
Keratinocyte growth factor (KGF) is a member of the heparin-binding fibroblast growth factor family (FGF-7) with a distinctive pattern of target-cell specificity. Studies performed in cell culture suggested that KGF was mitogenically active only on epithelial cells, albeit from a …
Keratinocyte growth factor: a unique player in epithelial repair ...
Keratinocyte growth factor (KGF) is a member of the rapidly growing fibroblast growth factor (FGF) family of mitogens. Whereas most FGFs influence proliferation and/or differentiation of various cell types, KGF seems to act specifically on epithelial cells.
Keratinocyte Growth Factor - an overview | ScienceDirect Topics
Keratinocyte growth factor (KGF) is a heparin-binding member of the fibroblast growth factor (FGF) family, in which it is termed FGF-7. KGF acts as a paracrine mitogen throughout the gastrointestinal tract and its mRNA and associated receptor have been detected in human adult and rodent gut tissue.
Keratinocyte Growth Factor-Based Strategies for Wound Re ...
2022年6月10日 · Keratinocyte growth factor (KGF) plays a central role in this problematic, as it is a potent factor that in the normal healing scenario promotes direct proliferation and migration of epidermal cells, consequently impacting re-epithelialization.
Expression and Function of Keratinocyte Growth Factor and …
2000年1月27日 · Recent studies from our laboratory provided evidence for an important role of keratinocyte growth factor (KGF) in the repair of the injured epithelium and for a novel function of the transforming growth factor-β superfamily member activin in granulation tissue formation.