Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). [5] Multiple transcript variants encoding …

2024年12月25日 · KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with KIT include Piebald Trait and Gastrointestinal Stromal Tumor. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Signaling by extracellular domain mutants of KIT.

The KIT gene provides instructions for making a member of a protein family called receptor tyrosine kinases. Receptor tyrosine kinases transmit signals from the cell surface into the cell through a process called signal transduction.

This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma vira l oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane ...

The KIT proto-oncogene maps to 4q12 and encodes the 145-kDA transmembrane receptor tyrosine kinase, KIT (CD117), the cellular homolog of the Hardy–Zuckerman 4 feline sarcoma viral oncogene, v-kit [1, 2].

The KIT-encoded transmembrane tyrosine kinase receptor for stem cell factor (SCFR) is required for normal hematopoiesis, melanogenesis, and gametogenesis. The role of individual KIT/SCFR-induced signaling pathways in the control of developmental processes in the intact animal were completely unknown.

Synonym (s): C-Kit, CD117, SCFR, mast/stem cell growth factor receptor Kit. Previous symbol (s) and name (s): PBT, piebald trait, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog. Type: gene with protein product. Chromosomal location: 4q12. OMIM: 164920. HGNC: 6342. UniProtKB: P10721. Genatlas: KIT. GenCC: KIT. Ensembl: ENSG00000157404

2022年9月16日 · c-kit is a classical proto-oncogene that encodes a receptor tyrosine kinase (RTK) that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell proliferation, survival, and migration and is implicated in several physiological processes, including pigmentation, hematopoiesis and gut movement.

2005年1月1日 · Kit is a receptor tyrosine kinase (RTK) that binds stem cell factor. This receptor ligand combination is important for normal hematopoiesis, as well as pigmentation, gut function, and reproduction. Structurally, Kit has both an extracellular and intracellular region.

KIT proto-oncogene, receptor tyrosine kinase - Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets.