Inactivation of LKB1 is associated with progression of PJS and transformation of benign polyps into malignant tumors. This study examines the effect of LKB1 on regulation of STAT3 and …

2023年8月12日 · Loss of Stat3 in a Pten-null mouse prostate model leads to a reduction of LKB1/pAMPK with simultaneous activation of mTOR/CREB, resulting in metastatic disease. …

2023年8月12日 · Loss of Stat3 in a Pten-null mouse prostate model leads to a reduction of LKB1/pAMPK with simultaneous activation of mTOR/CREB, resulting in metastatic disease. …

2014年6月9日 · A LKB1 promoter-luciferase construct and its truncations were used to assess transcriptional changes in response to specific siRNAs or inhibitors targeting Janus activated …

The increased activation of NF-κB and STAT3 pathways due to LKB1 loss could drive sensitivity to NF-κB and STAT3 inhibitors in clinical trials, such as TAS4464 and TTI-101, respectively. …

2014年6月9日 · A LKB1 promoter-luciferase construct and its truncations were used to assess transcriptional changes in response to specific siRNAs or inhibitors targeting Janus activated …

2017年10月10日 · We put forth HNK as a bioactive strategy to induce LKB1 and inhibit stem-like phenotype of breast cancer cells via reducing expression of iPSC inducers, in part, mediated …

2023年8月12日 · Loss of Stat3 in a Pten -null mouse prostate model leads to a reduction of LKB1/pAMPK with simultaneous activation of mTOR/CREB, resulting in metastatic disease. …

2022年8月26日 · Here we show that STAT3 converges with the LKB1/mTORC1 and CREB to control metastatic disease in PCa mouse models. Unexpectedly, STAT3 was found to be …

2019年3月25日 · Suppressing mTOR signaling and IL-6–STAT3 signaling partially rectified the abnormal Treg expansion and Th17 responses, respectively. Our results identify LKB1 as a …