Lactam - Wikipedia
A lactam is a cyclic amide, formally derived from an amino alkanoic acid through cyclization reactions. The term is a portmanteau of the words lactone + amide . Nomenclature
β-Lactam - Wikipedia
A lactam is a cyclic amide, and beta-lactams are named so because the nitrogen atom is attached to the β-carbon atom relative to the carbonyl. The simplest β-lactam possible is 2-azetidinone. β-lactams are significant structural units of medicines as manifested in many β-lactam antibiotics. [2]
Beta-Lactam Antibiotics - StatPearls - NCBI Bookshelf
2023年6月4日 · Beta-lactam antibiotics are used in the management and treatment of bacterial infections. This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) pertinent for members of an interprofessional ...
Overview of Beta-Lactams - Infectious Diseases - Merck Manual ...
Beta-lactamases are a diverse class of enzymes produced by bacteria that break open the beta-lactam ring, inactivating the beta-lactam antibiotic. Some beta-lactamases are encoded on mobile genetic elements (eg, plasmids); others are encoded on chromosomes.
Lactam - Synthesis, Structure, Types of Lactam and Uses of Lactam …
A lactam is a cyclic amide, which is derived from an amino alkanoic acid. The term is a portmanteau of the words acetone + amide. Lactams form by the acid-catalysed rearrangement of oximes in the Beckmann rearrangement.
β-Lactamases: Sequence, Structure, Function, and Inhibition
Rather than an active-site serine, these enzymes employ a hydroxide that is activated by coordination to the Zn(II) ion(s) as the nucleophile initiating β-lactam hydrolysis.
β-Lactam antibiotic - Wikipedia
β-Lactam antibiotics (beta-lactam antibiotics) are antibiotics that contain a β-lactam ring in their chemical structure. This includes penicillin derivatives , cephalosporins and cephamycins , monobactams, carbapenems [1] and carbacephems. [2]
Lactam - an overview | ScienceDirect Topics
A lactam is a cyclic amide, which can be found in different forms: α-lactam (three-atom rings), β-lactam (four-atom rings), γ-lactam (five-atom rings), δ-lactam (six-atom rings), and ɛ-lactam (seven-atom rings). From: Green Approaches in Medicinal Chemistry for …
β-Lactams and β-Lactamase Inhibitors: An Overview - PubMed
2016年8月1日 · β-Lactams are the most widely used class of antibiotics. Since the discovery of benzylpenicillin in the 1920s, thousands of new penicillin derivatives and related β-lactam classes of cephalosporins, cephamycins, monobactams, and carbapenems have been discovered.
Lactam: What Is It? A Lactam is a Variety of Cyclic Amide
The amino group at one end reacts with the carboxylic acid group at the other, closing the molecule to form the ring. This kind of ring is called a lactam. The type of lactam is designated by using a Greek letter prefix that indicating the number of carbons in the ring, not counting the carbonyl group.
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