Adverse skin reactions to low molecular weight heparins (LMWH) are rare even though their true incidence is probably underestimated because of under-reporting. These reactions may occur as an urticarial rash, presumably due to local histamine release or have the features of a classic type I immediat …

Heparin-induced skin lesions occur frequently in patients receiving subcutaneous heparin therapy. In most cases, heparin-induced skin lesions are caused by a delayed-type hypersensitivity reaction.

Adverse skin reactions to low molecular weight heparins (LMWH) are rare even though their true incidence is probably underestimated because of underreporting. These reactions may occur as an urticarial rash, presumably due to local histamine release or have the features of a classic type I immediate hypersensitivity reaction.

Heparin-induced skin necrosis is a rare complication of heparin injections either at the injection site or distant sites, in which there is the death of skin cells (necrosis) due to the inadequate blood supply.

Unfractionated heparin is more likely to cause heparin-induced thrombocytopenia than fractionated heparin (also called low molecular weight heparin). Investigations if suspicious of heparin-induced thrombocytopenia. Patients on heparin should have their blood count measured regularly to check platelet levels.