Major ABO-mismatched HSCT. A common complication associated with major ABO-mismatched HSCT is the transfusion of ABO incompatible erythrocytes that can cause hemolysis, acute renal failure and death 31. The transfusion strategy in ABO-mismatched cases should consider both the recipient and donor blood group systems 32.

2013年8月1日 · The major complications of major ABO-incompatible transplantation are hemolysis of red cells at the time of graft infusion, delayed red cell engraftment, and pure red cell aplasia (PRCA). All of these complications occur because of cross-reactivity between donor blood group antigens and recipient antibodies (isohemagglutinins).

Major ABO-incompatible HSCT (eg, from a type A, type AB, or type B donor to a type O recipient) is characterized by the presence of antidonor blood group antibodies in recipient plasma.

2021年11月5日 · Results: Of 4946 patients who met the study criteria, 2741 patients (55.4%) were ABO matched, 1030 patients (20.8%) had minor ABO mismatch, 899 patients (18.1%) had major ABO mismatch and 276 patients (5.6%) had bidirectional ABO mismatch.

2022年4月26日 · Major ABO mismatch is characterized by the presence of naturally existing host isohemagglutinins against the corresponding carbohydrate ABO antigens of the donor RBCs. The most common scenario is when a group O recipient receives a non-O graft; less commonly, a group A or B recipient may receive a B or A graft, respectively, or an AB graft.

All included patients met the following diagnostic criteria for PRCA: (1) reticulocytopenia <30 G/L for more than 60 days after HSCT in association with neutrophil recovery, (2) lack of erythroblasts in the bone marrow, (3) major or bidirectional ABO mismatch between donor and recipient, and (4) exclusion of other causes for the condition (e.g ...

According to ABO compatibility of donors and recipients, four groups were distinguished: match, major mismatch, minor mismatch and bidirectional ABO mismatch.

Three groups of ABO mismatch can be distinguished in HSCT: minor, major, and bidirectional ABO incompatibility. Minor ABO incompatibility (eg, from an type-O donor to a type-A, -B, or -AB recipient) is characterized by the ability of donor B lymphocytes to …

2016年2月1日 · Major ABO-mismatch is defined when the recipient's plasma exhibits IHAs against donor's erythrocyte antigens. The most common example for major ABO-mismatch is transplantation from a group-A donor to a group-O recipient.

2013年2月17日 · The major complications of major ABO-incompatible transplantation are hemolysis of red cells at the time of graft infusion, delayed red cell engraftment, and pure red cell aplasia (PRCA). All of these complications occur because of cross-reactivity between donor blood group antigens and recipient antibodies (isohemagglutinins).