It has now been shown that combining the MEST score with clinical data at biopsy provides the same predictive power as monitoring clinical data for 2 years; this requires further evaluation to assess earlier effective treatment intervention.

2022年1月11日 · The Oxford classification/MEST score is an established histopathologic scoring system for patients with IgA nephropathy (IgAN). The objective of this study was to derive a prognostic model for IgAN based on the MEST score and histopathologic features.

2015年6月16日 · Using modern prediction tools, we examined whether combining MEST with cross-sectional clinical data at biopsy provides earlier risk prediction in IgAN than current best methods that use 2 years of follow-up data.

The MEST-C scores show an association with clinical variables, notably hypertension with the S score, serum creatinine level and degree of hematuria with the E-, T-, and C-scores, and proteinuria with the T score, but their importance in prognostication and management is not clear.

The progression of immunoglobulin A nephropathy (IgAN) is currently assessed using the Oxford MEST-C score, which uses five indicators (mesangial and endocapillary hypercellularity, segmental sclerosis, interstitial fibrosis/tubular atrophy, and the ...

2016年12月8日 · In light of the recent data summarized here, we recommend the addition of a C (crescent score) to the MEST score. All adequate biopsy specimens with a diagnosis of IgAN should be scored as C0 (no crescents), C1 (crescents in a least 1 but <25% of glomeruli), or C2 (crescents in at least 25% of glomeruli) ( Tables 2 and 3 ).

2017年5月22日 · The IgAN Classification Working Group has now published an update to the Oxford Classification that recommends changing the MEST score to a MEST-C score 4, using the proposed definitions for C0,...

2021年2月11日 · The Oxford classification of IgA nephropathy (IgAN) can evaluate each MEST-C score individually. We analysed a new grading system that utilised the total MEST-C score in predicting renal...

2024年3月14日 · IgA nephropathy (IgAN) is the most common type of primary glomerulonephritis. The Oxford pathological classification, known as MEST-C score, is designed to predict prognosis of IgAN based on pathological factors. This study pointed out that only urinary protein level at diagnosis and T-score on biopsy could predict IgAN prognosis.

Table. MEST-C Score. Pathological Characteristics: Explanations: Scoring Criteria: Mesangial hypercellularity (M) ≥4 Mesangial cells in any mesangial area of a glomerulus ...