Where in the cell is the minor spliceosome? - PMC
The minor spliceosome excises ≈1 in 300 introns from human pre-mRNAs —which encode proteins with a wide range of functions —consistent with the lower abundance (≈1%) of its …
Spliceosomes: Current Biology - Cell Press
2015年3月2日 · Every human cell contains ∼100,000 spliceosomes, which are responsible for removing over 200,000 different intron sequences. Human cells contain two types of …
Structure of the activated human minor spliceosome | Science
The minor spliceosome mediates splicing of the rare but essential U12-type precursor messenger RNA. Here, we report the atomic features of the activated human minor spliceosome …
Minor Spliceosome - an overview | ScienceDirect Topics
The minor spliceosome refers to a small RNA/protein complex involved in the process of pre-mRNA splicing, which recognizes slightly different intronic sequences compared to the major …
Minor Spliceosome - an overview | ScienceDirect Topics
The minor spliceosome is a ribonucleoprotein complex that catalyses noncanonical splicing removing a typical class of introns (U12-type) during mRNA processing. From: Best Practice & …
At the Intersection of Major and Minor Spliceosomes: Crosstalk
2021年7月20日 · Minor introns coexist in the same genes with major introns and while the two intron types are spliced by separate spliceosomes, the two splicing machineries can interact …
Minor spliceosome, major surprise: it's cytoplasmic - PMC
2007年12月12日 · The minor spliceosome, found primarily in plants and animals, edits less than 1% of all introns, which are characterized by unique sequences at the splice sites. All genes …
Structural studies of the spliceosome: Bridging the gaps - PMC
Removal of the U12-dependent introns is conducted by the minor spliceosome, which contains four unique snRNAs (U11, U12, U4atac, and U6atac) that substitute for their major …
An early evolutionary origin for the minor spliceosome | Nature
2006年10月19日 · The minor spliceosome is a ribonucleoprotein complex that catalyses the removal of an atypical class of spliceosomal introns (U12-type) from eukaryotic messenger …
Minority report: The minor spliceosome as a novel cancer …
2023年6月15日 · The minor spliceosome regulates the removal of a conserved subset of introns present in genes with regulatory functions. In this issue of Molecular Cell, Augspach et al.1 …
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