Mitochondrial fission and fusion - PMC - PubMed Central (PMC)
In the present chapter we discuss the mechanisms behind mitochondrial fission and fusion, and discuss the implications of changes in organelle morphology during the life of a cell. In addition to their classic role as generators of ATP, mitochondria are central to several vital cellular functions.
Mechanisms of Mitochondrial Fission and Fusion - PMC
Fission and fusion are important for growth, for mitochondrial redistribution, and for maintenance of a healthy mitochondrial network. In addition, mitochondrial fission and fusion play prominent roles in disease-related processes such as apoptosis and mitophagy.
Mitochondrial fusion and fission in cell life and death
2010年11月23日 · Mitochondrial fission is mediated by dynamin-related proteins (DRPs) and cofactors that are required for assembly of DRP rings and spirals on the mitochondrial surface. Only little is known...
Mitochondrial Fusion and Fission: The fine-tune balance for …
Fission is essential for maintaining the mitochondrial number and proper distribution in the daughter cells, while fusion ensures optimal mitochondrial activity by allowing the exchange of contents between fusing mitochondria.
Mitochondrial Fission and Fusion: Molecular Mechanisms, …
2022年9月16日 · In this review, the molecular mechanisms and biological functions of mitochondrial fusion and fission are first discussed. Then, mitochondrial disorders caused by defects in fission and fusion are summarized, including disorders related to MFN2, MSTO1, OPA1, YME1L1, FBXL4, DNM1L, and MFF genes.
Mitochondrial fission and fusion dynamics: the long and short …
2008年4月25日 · Maintenance of functional mitochondria requires fusion and fission of these dynamic organelles. The proteins that regulate mitochondrial dynamics are now associated with a broad range of cellular...
Mitochondrial fusion and fission: The fine-tune balance for …
Mitochondrial fusion allows the transfer of gene products between mitochondria for optimal functioning, especially under metabolic and environmental stress. On the other hand, fission is crucial for mitochondrial division and quality control.
Mitochondrial fission and fusion dynamics: the long and short of it
Importance of mitochondrial fission and fusion. Mitochondrial fission and fusion are known to play roles in maintaining the (1) integrity of mitochondria, (2) electrical and biochemical connectivity, (3) turnover of mitochondria, and (4) segregation and protection of mitochondrial DNA (mtDNA). 1 – 3 Moreover, the fission and fusion machinery ...
Mitochondria, Fusion, Division | Learn Science at Scitable - Nature
Contrary to their illustration as ovoid structures in most textbooks, mitochondria are actually dynamic organelles that fuse and divide to form constantly changing tubular networks in most...
Mitochondrial fission and fusion: A dynamic role in aging and …
2020年3月1日 · Here, we discuss the mechanisms of mitochondrial fission and fusion, the current evidence of their role in aging of multicellular organisms, and how these connect to cell cycle regulation, quality control, and transmission of energy status.
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