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  1. Nature
    https://www.nature.com › articles

    Modulating mitofusins to control mitochondrial function and

    • Mitofusins reside on the outer mitochondrial membrane and regulate mitochondrial fusion, a physiological process that impacts diverse cellular processes. Mitofusins are activated by conformat… See more

    Introduction

    Mitochondria fuse, divide, and interact with other organelle structures to regulate cellular fitness and fate while they produce the majority of energy to sustain cellular activity1,2. … See more

    Nature
    Results

    A small molecule activator of mitochondrial fusion via mitofusins
    We previously generated … See more

    Nature
    Discussion

    Investigating the mechanisms of mitofusins regulation enables a deeper understanding of the critical function of mitofusins in mitochodrial dynamics, signaling, and related pat… See more

    Nature
    Methods

    Reagents
    MASM7 was obtained from Enamine (cat. # EN300-396282). Screened MASMs were purchased from Enamine, ChemBridge and ChemDiv. … See more

    Nature
    Do mitofusins regulate mitochondrial fusion?
    Mitofusins regulate mitochondrial fusion. Here the authors identify small molecules that activate or inhibit mitofusins’ activity and modulate mitochondrial fusion and functionality. Inhibition of mitochondrial fusion promotes minority MOMP, caspase-3/7 activation, and DNA damage.
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  1. Cell Press
    https://www.cell.com › cell › fulltext

    MTFP1 controls mitochondrial fusion to regulate inner …

    Jun 7, 2024 · Here, we demonstrate that the inner mitochondrial membrane (IMM) protein mitochondrial fission process 1 (MTFP1) negatively regulates IMM fusion. Moreover, manipulation of mitochondrial fusion through the regulation of …

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  3. Nature
    https://www.nature.com › articles

    Small molecule induces mitochondrial fusion for neuroprotection …

  4. ScienceDirect
    https://www.sciencedirect.com › science › article › pii

    Inhibition of mitochondrial fusion via SIRT1/PDK2/PARL axis …

  5. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    Inhibition of mitochondrial fusion is an early and critical event in ...

  7. Science | AAAS
    https://www.science.org › doi

    Epithelial OPA1 links mitochondrial fusion to inflammatory bowel ...

  8. nih.gov
    https://pmc.ncbi.nlm.nih.gov › articles

    Inhibitors of Mitochondrial Fission as a Therapeutic Strategy for ...

  9. Nature
    https://www.nature.com › articles

    Mitochondrial fusion is a therapeutic vulnerability of acute

  10. ScienceDirect
    https://www.sciencedirect.com › science › article › pii

    Inositol serves as a natural inhibitor of mitochondrial fission by ...

  11. stanford.edu
    https://techfinder.stanford.edu › technology

    First in class covalent inhibitor of Fis1 prevents mitochondrial ...

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