Since 1985, hundreds of monoclonal antibodies (mAbs) have been designated as drugs; new approvals continue to accrue. According to the World Health Organization (WHO), which is responsible for therapeutic mAb nomenclature, over 800 mAb names have been provided. (See 'Naming conventions' below.)

This review will examine IgE neutralization therapy with anti-IgE monoclonal antibody, with a focus on the treatment of asthma. Other promising approaches to reducing IgE, as well as investigational applications of anti-IgE to other disorders, will be discussed briefly.

INTRODUCTION. Parathyroid hormone (PTH) (1-84) is the biologically active hormone initially produced by the parathyroid glands as a 115-amino-acid polypeptide that undergoes two successive cleavages to yield the 84-amino-acid peptide, which is stored in the parathyroid cells.

Overview of therapeutic monoclonal antibodies; POEMS syndrome; Primary humoral immunodeficiencies: An overview; Severe combined immunodeficiency (SCID): An overview; Solitary plasmacytoma of bone; Structure of immunoglobulins; The heavy chain diseases; Treatment and prognosis of Waldenström macroglobulinemia

INTRODUCTION. Monoclonal B cell lymphocytosis (MBL) refers to a monoclonal population of B lymphocytes <5000 cells/microL (<5 x 10 9 /L) in peripheral blood for ≥3 months, without other features of a B cell lymphoproliferative disorder (eg, lymphadenopathy, organomegaly, cytopenias, or extramedullary involvement) [].. This topic will discuss the epidemiology, evaluation, diagnosis, prognosis ...

2024年4月17日 · Red blood cell antigens and antibodies; Refractoriness to platelet transfusion; RhD alloimmunization in pregnancy: Overview; RhD alloimmunization: Prevention in pregnant and postpartum patients; Selective IgA deficiency: Management and prognosis; Society guideline links: Immune thrombocytopenia (ITP) and other platelet disorders

2024年10月30日 · - Limited role for antibody-based therapies (monoclonal antibodies and convalescent plasma) - Others; MANAGEMENT OF HYPOXEMIA, ARDS, AND OTHER COMPLICATIONS; DISCHARGE; SPECIAL SITUATIONS. Pregnant and breastfeeding women; People with HIV; SOCIETY GUIDELINE LINKS; INFORMATION FOR PATIENTS; SUMMARY AND RECOMMENDATIONS; ACKNOWLEDGMENTS ...

2023年9月19日 · Measurement and clinical significance of antinuclear antibodies; Pathogenesis of primary biliary cholangitis (primary biliary cirrhosis) Primary sclerosing cholangitis in adults: Clinical manifestations and diagnosis; Screening and diagnosis of chronic hepatitis C virus infection; Society guideline links: Autoimmune hepatitis

INTRODUCTION. Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant clonal plasma cell or lymphoplasmacytic proliferative disorder characterized by the presence of monoclonal immunoglobulins and/or an abnormal ratio of free immunoglobulin light chains in the blood and/or urine.

Identification of LGL expansion has been improved using T-cell receptor (TCR)beta/gamma polymerase chain reaction (PCR) analysis and a combination of Vbeta and killer cell immunoglobulin-like receptor (KIR)-specific monoclonal antibodies.