Novobiocin: Uses, Interactions, Mechanism of Action - DrugBank …
2005年6月13日 · Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity.
Novobiocin - an overview | ScienceDirect Topics
Novobiocin is an antimicrobial drug that is structurally related to the coumarins. It is active against Gram-positive bacteria, such as Staphylococcus aureus (including meticillin-resistant strains) and other staphylococci; the enterococci are usually resistant.
The antibiotic novobiocin binds and activates the ATPase that …
Novobiocin is an orally active antibiotic that inhibits DNA gyrase by binding the ATP-binding site in the ATPase subunit. Although effective against Gram-positive pathogens, novobiocin has limited activity against Gram-negative organisms due to the ...
Testing Novobiocin in PARP Inhibitor-Resistant Cancers
2021年7月27日 · The antibiotic novobiocin showed promise as a treatment for cancers with BRCA mutations that have become resistant to PARP inhibitors. It will soon be tested in NCI-supported clinical trials. The drug inhibits a protein called Pol theta.
Novobiocin - an overview | ScienceDirect Topics
Novobiocin is an antimicrobial drug that is structurally related to the coumarins. It is active against Gram-positive bacteria, such as Staphylococcus aureus (including meticillin-resistant strains) and other staphylococci; the enterococci are usually resistant.
Definition of novobiocin - NCI Drug Dictionary - NCI
Novobiocin, as well as other aminocoumarin antibiotics, inhibits bacterial DNA synthesis by targeting at the bacteria DNA gyrase and the related enzyme DNA topoisomerase IV. This antibiotic was used to treat infections by gram-positive bacteria.
Novobiocin - an overview | ScienceDirect Topics
Novobiocin is an antibiotic that specifically targets DNA gyrase, a type of bacterial enzyme involved in DNA replication and repair. It inhibits the ATP hydrolysis of DNA gyrase, which is necessary for its proper function.
novobiocin | Dosing & Uses | medtigo
novobiocin is an antibiotic that primarily acts by inhibiting DNA gyrase, an enzyme involved in bacterial DNA replication and transcription. This inhibition disrupts DNA synthesis and cellular processes, leading to bacterial cell death.
Novobiocin | C31H36N2O11 | CID 54675769 - PubChem
Novobiocin is a coumarin -derived antibiotic obtained from Streptomyces niveus. It has a role as an antibacterial agent, an EC 5.99.1.3 [DNA topoisomerase (ATP -hydrolysing)] inhibitor, an antimicrobial agent, an Escherichia coli metabolite and a hepatoprotective agent.
Novobiocin blocks nucleic acid binding to Polθ and inhibits …
Novobiocin (NVB) is a first-in-class inhibitor of the Polθ ATPase activity, and it is currently being tested in clinical trials as an anti-cancer drug. Here, we investigated the molecular mechanism of NVB-mediated Polθ inhibition.
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