Osteoblasts have three main functions: Growing new bones (bone formation). Reshaping bones to help them change as you age (remodeling). Healing damaged or broken bones. Osteoblasts are triggered by chemical reactions or hormones when a bone grows or changes. They create and release (secrete) a mix of proteins called bone matrix.

2023年3月17日 · Osteoclast cells cause bone resorption and originate from a hematopoietic lineage, which includes multiple blood cell types from within the bone marrow. The cellular process of remodeling begins when osteoblast and osteoclast precursor cells fuse to form a multinucleated osteoclastic cell.

In bone, osteoclasts are found in pits in the bone surface which are called resorption bays, or Howship's lacunae. Osteoclasts are characterized by a cytoplasm with a homogeneous, "foamy" appearance. This appearance is due to a high concentration of vesicles and vacuoles. These vacuoles include lysosomes filled with acid phosphatase.

Bone remodeling is an ever-occurring event characterized by sequential coupling of osteoclasts and osteoblasts. Remodeling units are initiated by the appearance of osteoclasts. After degrading a packet of bone, the resorptive cells are replaced by osteoblasts, which synthesize new bone.

This comprehensive review provides insights into our evolving understanding of the osteoclast function, highlights the significance of clastokines in bone remodeling, and explores their potential as treatments for bone diseases suggesting future directions for the field.

2023年10月30日 · Osteoclasts are specialized bone matrix cells that possess the ability to erode bone, a process called resorption, during bone growth and remodeling. They are large, motile, multinucleated cells derived from the fusion of cells of the macrophage-monocyte cell line.

Destruction, or resorption, of bone by large cells called osteoclasts releases calcium into the bloodstream to meet the body’s metabolic needs and simultaneously allows the bone—which is inhibited by its inorganic component from growing by cell division like other tissues—to alter size and shape as it grows to adult proportions.

Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to regulate cellular behavior, survival and differentiation through …

2006年5月5日 · During bone resorption, the cytoskeleton of osteoclasts undergoes extensive reorganization, with polarization and formation of ruffled borders to secrete acid and formation of sealing zone to prevent leakage. The differentiation and function of osteoclasts are in turn regulated by osteoblasts, stromal cells, and bone.

2013年3月29日 · Osteoclasts, the bone-resorbing cells, play a pivotal role in skeletal development and adult bone remodeling. They also participate in the pathogenesis of various bone disorders.