p53 - Wikipedia
p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates , where they prevent cancer formation. [ 5 ]
Tumor Suppressor p53: Biology, Signaling Pathways, and …
TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of the DNA integrity of the cell. TP53 plays additional roles …
The p53 tumor suppressor protein - Genes and Disease - NCBI Bookshelf
In the cell, p53 protein binds DNA, which in turn stimulates another gene to produce a protein called p21 that interacts with a cell division-stimulating protein (cdk2). When p21 is complexed with cdk2 the cell cannot pass through to the next stage of cell division.
The Tumor Suppressor p53: From Structures to Drug Discovery
Here, we discuss key structural aspects of p53 function and its inactivation by oncogenic mutations. Concerted action of folded and intrinsically disordered domains of the highly dynamic p53 protein provides binding promiscuity and specificity, allowing p53 to process a myriad of cellular signals to maintain the integrity of the human genome.
Targeting p53 pathways: mechanisms, structures and advances in …
2023年3月1日 · In this review, we aim to provide a comprehensive summary of the biological function of p53, p53 signaling pathway, the structural features of p53 protein, as well as the advances in...
p53 Function and Dysfunction in Human Health and Diseases
The p53 protein is a sequence-specific DNA-binding transcription factor that, in response to stressful stimuli, regulates gene expression related to multiple cellular functions including, but not limited to, cell cycle arrest, cell apoptosis, cell growth, DNA repair, cell metabolism, and the immune response .
Tumor suppressor p53: Biology, signaling pathways, and ... - PubMed
The p53 pathway is a complex cellular stress response network with multiple diverse inputs and downstream outputs relevant to its role as a tumor suppressor pathway. While inroads have been made in understanding the biology and signaling in the p53 pathway, the p53 family, transcriptional readouts, and effects of an array of mutants, the ...
Versatile Functions of p53 Protein in Multicellular Organisms
The p53 protein is capable of several different functions, which collectively enforce the benefits of the whole organism through making sacrifice of individual cells. The p53 functions develop in evolution only in multicellular organisms.
Protein P53 - an overview | ScienceDirect Topics
p53 protein is a tumor suppressor encoded by a gene whose disruption is associated with ∼50–55% of all human cancers. p53 protein acts as a checkpoint in the cell cycle and regulates apoptosis. The release of E2F from pRb by T-Ag activates p14 ARF expression that leads to the stabilization of p53.
Regulation and function of the p53 tumor suppressor protein
2001年6月1日 · The p53 protein lies at the heart of stress response pathways that prevent the growth and survival of potentially malignant cells. Many types of stress activate p53, including DNA damage, telomere attrition, oncogene activation, hypoxia and loss of …