- Copilot AnswerPalbociclib, sold under the brand name Ibrance among others, is a medication developed by Pfizer for the treatment of HR-positive and HER2-negative breast cancer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. Palbociclib was the first CDK4/6 inhibitor to be approved as a cancer therapy.
Palbociclib-mediated cell cycle arrest can occur in the absence of …
Two main models explain how CDK4/6 inhibitors cause G1 cell cycle arrest, which differ in their dependence on the CDK inhibitor proteins p21 and p27. We have used live and fixed single …
Palbociclib-mediated cell cycle arrest can occur in the …
Nov 17, 2021 · In this study, we have established that a palbociclib-mediated cell cycle arrest is not dependent on the Cip/Kip inhibitor proteins p21 and p27 in …
- Author: Betheney R. Pennycook, Alexis R. Barr
- Publish Year: 2021
Therapeutic evaluation of palbociclib and its compatibility with …
The levels of multiple protein markers associated with the cell cycle, differentiation and apoptosis were analyzed by Western blotting. Palbociclib monotherapy inhibited cell cycle progression in …
Release from cell cycle arrest with Cdk4/6 inhibitors …
Oct 14, 2020 · We show how these challenges are avoided by exploiting the ability of the Cdk4/6 inhibitors, palbociclib, ribociclib and abemaciclib to arrest …
- Author: Eleanor Wendy Trotter, Iain Michael Hagan
- Publish Year: 2020
TMEM45A enhances palbociclib resistance and cellular glycolysis …
Western blotting. Cell proteins were extracted by lysing cells on ice with RIPA lysis buffer (P013B, Beyotime, China) containing 1% protease inhibitors and phosphatase inhibitors. ... were …
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TMEM45A enhances palbociclib resistance and cellular ... - Nature
Feb 5, 2025 · Silencing TMEM45A enhances sensitivity to palbociclib, promotes cell cycle arrest and apoptosis, and inhibits the proliferation of BRCA cells. ... Western blotting. Cell proteins …
The CDK4/6 Inhibitor Palbociclib Induces Cell Senescence of
Feb 22, 2024 · The results showed that Palbociclib inhibited cell viability, blocked cell cycle at G0/G1 phase, and induced cell senescence. A rescue study indicated that knockdown of p53 …
The CDK4/6 Inhibitor Palbociclib Induces Cell Senescence of
Acetylation of p53 was evaluated by qPCR and western blot. The results showed that Palbociclib inhibited cell viability, blocked cell cycle at G0/G1 phase, and induced cell senescence. A …
Expanding control of the tumor cell cycle with a CDK2/4/6 …
Sep 13, 2021 · We interrogated mechanisms of PALR through parallel evaluation of preclinical models, tumor biopsies, and matched patient response profiles. A total of 168 cell-cycle …
[Palbociclib induces cell cycle arrest and senescence of human …
Dec 13, 2020 · RT-PCR and Western blotting showed that palbociclib treatment significantly increased the mRNA and protein expression levels of P16, P21, and P53 in HK-2 cells (P < …
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