Lupus nephritis, one of the most serious manifestations of systemic lupus erythematosus (SLE), usually arises within 5 years of diagnosis; however, renal failure rarely occurs before American...

Lupus nephritis is glomerulonephritis caused by systemic lupus erythematosus (SLE). Clinical findings include hematuria, nephrotic-range proteinuria, and, in advanced stages, azotemia. Diagnosis is based on renal biopsy.

2021年4月13日 · Pathophysiology of Lupus Nephritis The critical step in lupus nephritis is the occurrence of antigen-antibody complexes in the kidney Previously, it was thought that autoantibodies bind to circulating antigens, and these then deposit in the kidney

Lupus nephritis is an inflammation of the kidneys caused by systemic lupus erythematosus ... The pathophysiology of lupus nephritis has autoimmunity contributing significantly. Autoantibodies direct themselves against nuclear elements. The characteristics of nephritogenic autoantibodies ...

2024年8月18日 · This review aims to provide a comprehensive update on progress on several key aspects in this setting: pathogenetic mechanisms of LN, including new insight into the role of autoantibodies, complement, vitamin D deficiency, and interaction between infiltrating immune cells and kidney resident ones; the evolving role of renal biopsy and biomarkers...

2021年6月11日 · Lupus nephritis (LN) is a form of glomerulonephritis that constitutes one of the most severe organ manifestations of the autoimmune disease systemic lupus erythematosus (SLE). Lupus nephritis is present in approximately 25% of patients at the time of diagnosis and eventually develops in up to 60% of adults and 80% of children.

2024年7月13日 · From a clinical point of view, the disease is characterized by a greater severity at onset, with aggressive multiorgan involvement, lower responsiveness to classical therapies, and more frequent flares, as compared to adults [16–18].

2021年4月5日 · Lupus nephritis (LN), a major cause of morbidity and mortality in patients with SLE, affects up to 60% of patients. The recent insights into the genetic and molecular basis of SLE and LN paved the way for newer therapies to be developed for these patients.

Pathophysiologically, progressive renal damage may be divided into immune-mediated and non-immune-mediated pathways. Immune-mediated events may be classified as cell-based or small molecule-based. Immune-independent events may be triggered by hypertension or proteinuria.

Lupus nephritis is kidney inflammation due to lupus, an autoimmune disease. Symptoms can include fluid buildup in your body and increased urine output. About half of adults and 80% of children with lupus will develop lupus nephritis.