Piritramide - Wikipedia
Piritramide [3] (R-3365, trade names Dipidolor, Piridolan, Pirium and others) is a synthetic opioid analgesic (narcotic painkiller) that is marketed in certain European countries including: Austria, Belgium, Czech Republic, Slovenia, Germany and the Netherlands. [4]
Piritramide: Uses, Interactions, Mechanism of Action - DrugBank …
Oct 20, 2016 · Piritramide is a synthetic opioid used in the treatment of severe pain. Piritramide is under investigation for the treatment of Colon Cancer and Minimal Residual Disease. Piritramide has been investigated for the supportive care of Pain, …
[Piritramide : A critical review] - PubMed
Results: Piritramide is a strong opioid that can only be administered parenterally. After intravenous injection it is effective after 17 min with pain relief lasting for up to 6 h. It is metabolized in the liver to inactive compounds, which is advantageous compared to morphine where active metabolites can accumulate in patients with renal failure.
PIRITRAMIDE Solution for injection Usage - RxReasoner
Piritramide can be used for single and repeated intramuscular, subcutaneous and intravenous administration. Intramuscular, subcutaneous and intravenous single doses can usually be repeated after 6-8 hours if the effect is fading.
Piritramide | C27H34N4O | CID 9331 - PubChem
Piritramide | C27H34N4O | CID 9331 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
PIRITRAMIDE - National Center for Advancing Translational …
Piritramide is most commonly prescribed i.m. or i.v. for postoperative analgesia. It is used successfully for patient-controlled analgesia in adults 14 and more recently in chil-dren. Piritramide has potency 0.65 to 0.75 times that of morphine.
Piritramide - an overview | ScienceDirect Topics
Piritramide Respiratory. When piritramide (mean dose 64 micrograms/kg) was given to 39 neonates and infants for postoperative analgesia, respiratory depression occurred in one case [157 c].
Definition of piritramide - NCI Drug Dictionary - NCI
A diphenylpropylamine and opioid receptor agonist, with analgesic activity. Upon administration, piritramide binds to and activates mu-opioid receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids and producing analgesic relief.
PIRITRAMIDE Solution for injection Pharmacology - MPI, EU: …
Piritramide is a pure µ-opioid receptor agonist, which has a slightly less analgesic potency than morphine. Analgesia results from activation of the µ-opioid receptors in the spine and the higher pain centres such as the thalamus and cerebral cortex, thereby raising the pain threshold and the sensitivity to pain.
[Piritramide : A critical review]. - Abstract - Europe PMC
Aug 1, 2017 · In many European countries and particularly in Germany, piritramide is the first choice opioid analgesic for the management of postoperative and posttraumatic pain.
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