Protein kinase A - Wikipedia
Protein kinase A, more precisely known as adenosine 3',5'-monophosphate (cyclic AMP)-dependent protein kinase, abbreviated to PKA, was discovered by chemists Edmond H. Fischer and Edwin G. Krebs in 1968.
Physiological and pathological roles of protein kinase A in the heart
Protein kinase A (PKA) is a central regulator of cardiac performance and morphology. Myocardial PKA activation is induced by a variety of hormones, neurotransmitters, and stress signals, most notably catecholamines secreted by the sympathetic ...
Protein Kinase A - an overview | ScienceDirect Topics
Protein Kinase A is a key enzyme that is defined as the primary target of cyclic AMP in the brain, playing a crucial role in regulating protein kinase production and activity, as well as influencing the balance between kinase and phosphatase functions essential for brain activity.
Protein Kinase A - Madame Curie Bioscience Database - NCBI Bookshelf
Among these general cellular mechanisms, enzymatic cascades including the cAMP-dependent protein kinase (protein kinase A, PKA) signaling pathway in CA1 region of the hippocampus have been demonstrated to be crucial to memory processing.
Functional Insights into Protein Kinase A (PKA) Signaling from
Protein kinase A (PKA) is a 3′-5′-cyclic adenosine monophosphate (cAMP)-dependent kinase that is at the center of diverse biological functions in numerous systems. Inactive PKA is composed of two catalytic (PKA-C) and two regulatory (PKA-R) subunits.
The Tails of Protein Kinase A - PMC - PubMed Central (PMC)
Protein kinase A (PKA) is a holoenzyme consisting of a regulatory (R)-subunit dimer and two catalytic (C)-subunits. There are two major families of C-subunits, Cα and Cβ, and four functionally nonredundant R-subunits (RIα, RIβ, RIIα, RIIβ). In ...
Protein Kinase A - an overview | ScienceDirect Topics
Protein kinase A (PKA), also known as cAMP-dependent protein kinase, was one of the first protein kinases to be discovered (Walsh et al., 1968). PKA is a heterotetramer containing two catalytic subunits (PKA-C) and a dimer of regulatory subunits (R).
Protein Kinase A - Colorado State University
Like other protein kinases, protein kinase A (also known as the cyclic AMP-dependent protein kinase or A kinase) is an enzyme that covalently decorates proteins with phosphate groups. The unique characteristic of protein kinase A is that its activity is regulated by fluctuating levels of cyclic AMP within cells (hence its alias as the cyclic ...
Molecule of the Month: cAMP-dependent Protein Kinase (PKA)
Protein kinases are used to add phosphate groups to proteins. The one shown here is cAMP-dependent protein kinase, also known as protein kinase A or PKA (PDB entries 3tnp , 1j3h and 2h9r ). It is composed of two types of subunits.
Targeting protein kinase A in cancer therapy: an update
Aug 18, 2014 · Protein Kinase A (PKA) is a well known member of the serine-threonin protein kinase superfamily. PKA, also known as cAMP-dependent protein kinase, is a multi-unit protein kinase that mediates signal transduction of G-protein coupled receptors through its activation upon cAMP binding.