ROR1 - Wikipedia
Tyrosine-protein kinase transmembrane receptor ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is an enzyme that in humans is encoded by the ROR1 gene. [5] [6] [7] ROR1 is a member of the receptor tyrosine kinase-like …
ROR1 Gene - GeneCards | ROR1 Protein | ROR1 Antibody
2024年12月25日 · ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1) is a Protein Coding gene. Diseases associated with ROR1 include Deafness, Autosomal Recessive 108 and Rare Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are GPCR Pathway and ERK Signaling.
Analysis of ROR1 Protein Expression in Human Cancer and …
2017年6月15日 · ROR1 is considered a promising target for cancer therapy due to putative tumor-specific expression, and multiple groups are developing antibodies and/or chimeric antigen receptor-modified T cells to target ROR1.
ROR1: an orphan becomes apparent | Blood - American Society of …
2022年10月6日 · Since its initial identification in 1992 as a possible class 1 cell-surface receptor without a known parent ligand, receptor tyrosine kinase–like orphan receptor 1 (ROR1) has stimulated research, which has made apparent its significance in embryonic development and …
Zilovertamab Vedotin Targeting of ROR1 as Therapy for Lymphoid …
2021年10月12日 · Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncofetal protein present on many cancers. Zilovertamab vedotin (ZV) is an antibody–drug conjugate comprising a monoclonal...
ROR1 receptor tyrosine kinase like orphan receptor 1 [ (human)]
ROR1 is an accurate and reliable marker of minimal residual disease in chronic lymphocytic leukaemia. LncRNA ROR1-AS1 promotes colon cancer cell proliferation by suppressing the expression of DUSP5/CDKN1A. ROR1 is upregulated in endometrial cancer and represents a novel therapeutic target.
Analysis of ROR1 protein expression in human cancer and normal tissues
This study examines cell-surface ROR1 expression in human tumors and normal tissues. ROR1 is considered a promising target for cancer therapy due to putative tumor-specific expression and multiple groups are developing antibodies and/or chimeric ...
Therapeutic advances in the targeting of ROR1 in hematological …
2024年11月17日 · Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) is highly expressed during embryonic development and is involved in cell differentiation, which leads to the formation of,...
Receptor tyrosine kinase-like orphan receptor 1: A novel ... - PubMed
2024年5月24日 · Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the type I receptor tyrosine kinase family. ROR1 is pivotal in embryonic development and cancer, and serves as a biomarker and therapeutic target.
The Ror-Family Receptors in Development, Tissue Regeneration …
In this article, we overview recent advances in our understanding of the roles of Ror1 and Ror2-mediated signaling in the development, tissue regeneration and age-related diseases, and discuss their potential to be therapeutic targets for chronic inflammatory diseases and cancers.