The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic

A characteristic region of RHO family GTPases is the insert helix (amino acids 124–136, RHOA numbering), which may play a role in effector activation and downstream processes .

Jul 20, 2021 · Identified and structurally verified hotspots as functional determinants specific to RHO GTPase regulation by GDIs, GEFs, and GAPs as well as signaling through effectors are presented, and challenges and future perspectives are discussed.

In mammals, the Rho family of GTPases has 23 members, which are regulated by 79 guanine nucleotide exchange factors (GEFs), 65 GTPase activating proteins (GAPs) and 3 guanine nucleotide dissociation inhibitors (GDIs).

Aug 21, 2009 · In mammals, the Rho family of GTPases has 23 members, which are regulated by 79 guanine nucleotide exchange factors (GEFs), 65 GTPase-activating proteins (GAPs) and 3 guanine nucleotide...

The Rho family of GTPases belongs to the Ras superfamily of low molecular weight (∼21 kDa) guanine nucleotide binding proteins. The most extensively studied members are RhoA, Rac1, and Cdc42.

The Rho family of GTPases (Rho, Rac and Cdc42) is a group of regulatory molecules that link surface receptors to downstream effectors regulating actin cytoskeletal structure.

Rho GTPase family members mediate signal transduction and cytoskeletal remodeling related to a broad spectrum of cellular processes in different cell types. The Rho family of GTPases is a family of small signaling G proteins, whose activity is controlled by GTP or GDP binding.

Dec 1, 2012 · Rho GTPases comprise a family of molecular switches that control signal transduction pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes an interaction with target (effector) proteins to generate a cellular response.

Jun 15, 2016 · Rho GTPases regulate cytoskeletal and cell adhesion dynamics and thereby coordinate a wide range of cellular processes, including cell migration, cell polarity and cell cycle progression.