SCN9A gene - MedlinePlus
The SCN9A gene belongs to a family of genes that provide instructions for making sodium channels. These channels, which transport positively charged sodium atoms (sodium ions) into cells, play a key role in a cell's ability to generate and transmit electrical signals.
Sodium voltage-gated channel alpha subunit 9 - Wikipedia
Sodium voltage-gated channel alpha subunit 9 (also Na v 1.7) is a sodium ion channel that, in humans, is encoded by the SCN9A gene.
SCN9A Neuropathic Pain Syndromes - GeneReviews® - NCBI Bookshelf
2006年5月6日 · SCN9A neuropathic pain syndromes (SCN9A-NPS) comprise SCN9A erythromelalgia (EM), SCN9A paroxysmal extreme pain disorder (PEPD), and SCN9A small fiber neuropathy (SFN).
SCN9A Gene - GeneCards | SCN9A Protein | SCN9A Antibody
2024年12月25日 · SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9) is a Protein Coding gene. Diseases associated with SCN9A include Paroxysmal Extreme Pain Disorder and Erythermalgia, Primary. Among its related pathways are Activation of cAMP-Dependent PKA and Neuropathic Pain-Signaling in Dorsal Horn Neurons.
SCN9A sodium voltage-gated channel alpha subunit 9 [ (human)]
Gene ID: 6335, updated on 10-Dec-2024. This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]
The voltage-gated sodium-channel type IX α subunit, known as Nav1.7 and encoded by the gene SCN9A, is located in peripheral neurons and plays an important role in action potential produc-tion in these cells. Recent genetic studies have identified Nav1.7 dysfunction in three different human pain disorders.
Channelopathy-associated congenital insensitivity to pain
The SCN9A gene provides instructions for making one part (the alpha subunit) of a sodium channel called NaV1.7. Sodium channels create an opening in the cell membrane to transport positively charged sodium atoms (sodium ions) into cells.
These channels, which transport positively charged sodium atoms ( sodium ions) into cells, play a key role in a cell's ability to generate and transmit electrical signals. The SCN9A gene provides instructions for making one part (the alpha subunit) of a sodium channel called NaV1.7.
SCN9A sodium voltage-gated channel alpha subunit 9 [Homo …
2024年12月10日 · This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to …
Mutations in sodium-channel gene SCN9A cause a spectrum of …
2007年12月3日 · The voltage-gated sodium-channel type IX α subunit, known as Na v 1.7 and encoded by the gene SCN9A, is located in peripheral neurons and plays an important role in action potential production in these cells.