SIRT1 is an enzyme located primarily in the cell nucleus that deacetylates transcription factors that contribute to cellular regulation (reaction to stressors, longevity). [8][9] Sirtuin 1 is a member of the sirtuin family of proteins, homologs of the Sir2 gene in S. cerevisiae.

2022年12月29日 · Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological...

SIRT1 is a NAD+-dependent protein deacetylase that has a very large number of established protein substrates and an equally impressive list of biological functions thought to be regulated by its activity.

SIRT1 protein, a member of Silent Information Regulator 2 (Sir2) protein family, have gained considerable attention as epigenetic regulators for a great area in the human physiology. Changes in sirtuin expression are critical in several diseases, ...

SIRT1 is a NAD+-dependent deacetylase that plays important roles in many cellular processes. SIRT1 activity is uniquely controlled by a C-terminal regulatory segment (CTR). Here we present crystal structures of the catalytic domain of human SIRT1 in ...

Sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase that regulates physiological processes by modifying gene expression through histone deacetylation. It plays a crucial role in protecting against neurodegenerative diseases by influencing various pathways related to aging, oxidative stress, and inflammation.

2024年12月25日 · SIRT1 (Sirtuin 1) is a Protein Coding gene. Diseases associated with SIRT1 include Mitochondrial Complex I Deficiency, Nuclear Type 33 and Aging. Among its related pathways are Epigenetic regulation by WDR5-containing histone modifying complexes and MITF-M-dependent gene expression.

2011年5月8日 · Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase that removes acetyl groups from various proteins. Sirt1 performs a wide variety of functions in biological systems.

2024年3月6日 · Silent information regulator 1 (SIRT1) is a NAD + -dependent class III deacetylase that plays important roles in the pathogenesis of numerous diseases, positioning it as a prime candidate...

2021年4月14日 · We found that SIRT1 promoted mitochondrial biogenesis and respiration in adipocytes and expression of molecules like leptin, adiponectin, matrix metalloproteinases, lipocalin 2, and thyroid...