In 10 patients, bronchoalveolar lavage at presentation showed a considerable amount of proteinaceous material with a positive reaction to periodic acid–Schiff (PAS) stain. Necropsy performed in three cases revealed intraalveolar accumulation of PAS-positive proteinaceous material, mild peribronchial granulomatous inflammation, and a few ...

As shown in Fig. 1 A, HE staining of silicosis patients showed a severe bronchoalveolitis with numerous of leukocytes around the bronchial and alveolar interstitial compared to normal individuals (Fig. 1 A). Consistently, inflammatory cytokines (TNF-α, IL-1β, IL-6) were significantly up-regulated in lung tissues of silicosis patients (Fig. 1 C).

Silica-induced inflammatory activation is associated with silicosis and various non-respiratory conditions. The present study was designed to examine the anti-inflammatory effects of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) on lung ...

Hematoxylin and eosin (H&E) and Masson trichrome staining at 28 days (d28) and d56 postchallenge confirmed that i.t. silica induces patchy but extensive interstitial and intra-alveolar inflammation composed predominantly of lymphocytes and macrophages. The alveolar spaces were filled with abundant enlarged macrophages admixed with granular ...

riodic acid–Schiff (PAS) stain. Necropsy performed in three cases revealed intraalveolar accumulation of PAS-positive proteinaceous material, mild peribron-chial granulomatous inflammation, and a few silica particles (Fig. 1). High-resolution CT examinations were per-formed with different scanners but similar proto-