Systemic Inflammation: A Driver of Neurodegenerative Disease?
When systemic inflammation strikes, perivascular macrophages (purple) and endothelial cells kick the primed microglia into overdrive (right panel). [Image courtesy of Perry and Holmes, Nature …
Systemic inflammation and disease progression in Alzheimer …
Sep 29, 2009 · These data provide powerful evidence—from 300 community-based AD patients—that systemic inflammation associates with exacerbated cognitive decline in AD. …
Inflammation in Midlife Portends Late-Life Brain Shrinkage
Nov 22, 2017 · Our own and others’ research shows that systemic inflammation, highlighted by an increase in TNFα, is associated with cognitive decline in AD (Holmes et al., 2009). Blockade of …
With Age, Microglia Pump cGAS, Revving Harmful Inflammation
Aug 18, 2023 · In 20- to 26-month-old mice, H-151 counteracted systemic inflammation, bolstered kidney function, boosted strength and endurance, and improved spatial memory. It also …
Gut Microbes: The Difference Between Life and Death in
May 22, 2020 · In Baloh’s lab, similarly generated C9-deficient mice developed telltale signs of systemic inflammation, including an enlarged spleen and lymph nodes, but lived a normal …
Etanercept - ALZFORUM
The rationale of evaluating peripheral administration of etanercept as a treatment for Alzheimer's disease derives from studies suggesting that low-grade, chronic, systemic inflammation …
C9ORF72 Knockout Causes Inflammation, not Neurodegeneration
Mar 25, 2016 · They also produced high levels of the inflammatory cytokines IL-6 and IL-1b. To find additional evidence of inflammation, the authors compared gene expression profiles …
Systemic inflammation accelerates neurodegeneration in a rat …
Systemic inflammation accelerates neurodegeneration in a rat model of Parkinson's disease overexpressing human alpha synuclein. NPJ Parkinsons Dis. 2024 Nov 5;10(1):213. PubMed. …
Blessing or Curse? Peripheral Cytokines in the Brain
Clive Holmes, University of Southampton, U.K., discussed an idea he has pursued for some time, namely that systemic inflammation can lead to central nervous system disease, including …
Myeloid Metabolic Crisis May Trigger Cognitive Decline in Aging …
Jan 23, 2021 · It is unclear how impaired glycolysis or respiration promotes inflammation, but the authors noted that suppression of the electron transport chain boosts levels of the intermediate …