In cardiology, T wave alternans (TWA) is a periodic beat-to-beat variation in the amplitude or shape of the T wave in an electrocardiogram (ECG or EKG). TWA was first described in 1908. At that time, only large variations ("macroscopic" TWA) could be detected.

Non-invasive measurement of beat-to-beat alternation of the electrocardiographic T-wave, referred to as T-wave alternans (TWA), is an important marker of risk for sudden cardiac death (SCD). Is this relationship a mere association or is TWA mechanistically linked to SCD?

2024年9月26日 · T-wave alternans (TWA) refers to periodic beat-to-beat variability in the timing, shape, and/or amplitude of T-waves on the surface electrocardiogram (ECG) [1,2]. TWA …

2022年7月25日 · T-wave alternans (TWA) refers to periodic beat-to-beat variability in the timing, shape, and/or amplitude of T-waves on the surface electrocardiogram (ECG) [1,2]. TWA therefore reflects sudden changes in temporal heterogeneity in ventricular repolarization, which is an important mechanism underlying reentrant arrhythmias [3,4].

Clinically, T-wave alternans (TWA) is the most common form of cardiac electrical alternans. It is associated with the dispersion of repolarization and can be used as a biomarker to predict malignant arrhythmias and sudden cardiac death (SCD; Hekkanen et al., 2020).

T-wave alternans, a manifestation of repolarization alternans at the cellular level, is associated with lethal cardiac arrhythmias and sudden cardiac death.

It discusses the electrocardiographic phenomenon of T-wave alternans (TWA) (i.e., a beat-to-beat alternation in the morphology and amplitude of the ST- segment or T-wave). This statement focuses on its physiological basis and measurement technologies and its clinical utility in stratifying risk for life-threatening ventricular arrhythmias.

We review the contemporary understanding of the pathophysiology of repolarization alternans and present a perspective on the use of T-wave alternans (TWA) as a risk stratification marker of malignant ventricular arrhythmias.

T-wave alternans, an integral component of congenital long QT syndrome, is a phenomenon of beat-to-beat variability in T-wave amplitude, morphology, and sometimes polarity that can trigger life-threatening ventricular arrhythmias.

T-wave alternans (TWA) is a promising ECG index that indicates risk for SCA from beat-to-beat alternations in the shape, amplitude, or timing of T waves. Decades of research now link TWA clinically with inducible [2–4] and spontaneous [5–7] ventricular arrhythmias, and with basic mechanisms leading to their initiation [8, 9].