TCF3 - Wikipedia
Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. [5][6][7] TCF3 has been shown to directly enhance Hes1 (a well-known target of Notch signaling) expression. [8]
TCF3 Gene - GeneCards | TFE2 Protein | TFE2 Antibody
2024年12月25日 · TCF3 (Transcription Factor 3) is a Protein Coding gene. Diseases associated with TCF3 include Agammaglobulinemia 8A, Autosomal Dominant and Agammaglobulinemia 8B, Autosomal Recessive. Among its related pathways are …
TCF3 haploinsufficiency defined by immune, clinical, gene-dosage, …
TCF3 is a transcription factor contributing to early lymphocyte differentiation. Germline monoallelic dominant negative and biallelic loss-of-function (LOF) null TCF3 mutations cause a fully penetrant severe immunodeficiency.
TCF3 transcription factor 3 [ Homo sapiens (human) ]
2025年1月5日 · Title: TCF3 haploinsufficiency defined by immune, clinical, gene-dosage, and murine studies. Molecular characterization of TCF3::PBX1 chromosomal breakpoints in acute lymphoblastic leukemia and their use for measurable residual disease assessment.
TCF3, a novel positive regulator of osteogenesis, plays a crucial …
TCF3 acts as a positive regulator of osteogenesis both in vitro and in vivo. The role of TCF3 in miR-17 modulating the different effect of canonical Wnt signaling and the increased level of TCF3 during osteogenic differentiation prompted us to investigate its function in
Entry - *147141 - TRANSCRIPTION FACTOR 3; TCF3 - OMIM
The TCF3 gene, also called E2A, encodes 2 basic helix-loop-helix (bHLH) transcription factors, E12 and E47, through alternative splicing. E12 and E47 are involved in regulation of immunoglobulin gene expression (Bain et al., 1994). TCF3 plays an important role in B-cell development and differentiation (summary by Ben-Ali et al., 2017).
2023年6月3日 · We identified 8 individuals from 7 unrelated families with monoallelic LOF TCF3 variants presenting with immunodeficiency with incomplete clinical penetrance. Objective: We sought to define TCF3 haploinsufficiency (HI) biology and its association with immunodeficiency. Methods: Patient clinical data and blood samples were analyzed.
TCF3 transcription factor 3 - NIH Genetic Testing Registry (GTR)
2024年6月9日 · Clinical resource with information about TCF3, A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus., Agammaglobulinemia 8, autosomal dominant, Agammaglobulinemia 8b, autosomal recessive, and available tests.
6929 - Gene ResultTCF3 transcription factor 3 [ (human)]
Transcription factor 3 is dysregulated in megakaryocytes in myelofibrosis. Rare TCF3 variants associated with pediatric B cell acute lymphoblastic leukemia. Transcription Factor TCF3 Promotes Macrophage-Mediated Inflammation and MMP Secretion in Abdominal Aortic Aneurysm by Regulating miR-143-5p /CCL20.
T-Cell Factor 3 Regulates Embryonic Stem Cell Pluripotency and …
In this study, we identified new regulatory targets of Tcf3 using a whole-genome approach and found that Tcf3 transcriptionally represses many genes important for maintaining pluripotency and self-renewal, as well as those involved in lineage commitment and stem cell differentiation.