What is talin? - Mechanobiology Institute, National University of …
2023年11月30日 · What is talin? Talin contains a 47-kDa N-terminal head, a neck and a 220kDa rod domain. The head domain comprises four subdomains termed F0, F1, F2 and F3, with the …
The Architecture of Talin1 Reveals an Autoinhibition Mechanism - Cell …
2019年9月19日 · To understand how talin function is regulated, we determined a cryoelectron microscopy (cryo-EM) structure of full-length talin1 revealing a two-way mode of autoinhibition. …
Talin in mechanotransduction and mechanomemory at a glance
2021年10月28日 · In this Cell Science at a Glance article, we briefly review talin structure, function, interactions and mechanical properties, before describing a novel view of talin as a …
Crystal structure of the FERM-folded talin head reveals the ... - PNAS
2020年12月7日 · Here, we present a crystal structure of a full-length talin head in complex with the β3-integrin tail. The structure reveals a compact FERM-like conformation and a tightly …
Talin – the master of integrin adhesions | Journal of Cell Science ...
2017年8月1日 · Talin forms the core of integrin adhesion complexes by linking integrins directly to actin, increasing the affinity of integrin for ligands (integrin activation) and recruiting numerous …
Sequence and domain structure of talin - Nature
1990年10月18日 · To learn more about the structure of talin and its involvement in transmembrane connections between extracellular adhesions and the cytoskeleton, we have …
Talin: Structural and Functional Relationships | Cell and Tissue …
2021年9月24日 · Talin is an adapter protein that contains the head domain, which is an atypical FERM domain, and rod domain, consisting of coiled bundles constructed of four or five α …
The Talin Dimer Structure Orientation Is Mechanically Regulated
2014年10月10日 · Formation of a stable cell-substrate contact can be regulated by mechanical force, especially at the focal adhesion. Individual proteins that make up the focal adhesions, …
The interaction of talin with the cell membrane is essential for ...
2018年10月10日 · To understand the mechanism of integrin activation by talin, we determined the crystal structure of the talin head domain bound to the acidic phospholipid phosphatidylinositol …
Sequence and domain structure of talin - PubMed
1990年10月18日 · Talin is a high-molecular-weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. Integrin receptors are …
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