Targeted protein degradation: mechanisms, strategies and …
2022年4月4日 · Targeted protein degradation (TPD), via the proteasomal and lysosomal pathways, represent a novel tool to explore cellular pathways and a promising therapeutic approach. 29 The concept of TPD was...
Targeted protein degradation: from mechanisms to clinic
2024年4月29日 · Two distinct classes of protein degradation therapeutics are being widely explored: bifunctional PROTACs and molecular glue degraders, both of which have their unique advantages and challenges....
Targeted protein degradation: current molecular targets, …
2024年11月1日 · Targeted protein degradation (TPD) has revolutionized drug discovery by selectively eliminating specific proteins within and outside the cellular context. Over the past two decades, TPD has expanded its focus beyond well-established targets, exploring diverse proteins beyond cancer-related ones.
Targeted protein degradation comes of age - Nature
5 天之前 · Enabling protein degradation with small-molecule drugs has emerged as an innovative approach to the development of therapeutics against otherwise intractable targets. Two landmark studies that ...
Targeted protein degradation: from mechanisms to clinic
Here, we review the current landscape of targeted protein degradation approaches and how they have parallels in biological processes. We also outline the ongoing clinical exploration of novel degraders and provide some perspectives on the directions the field might take.
Targeted protein degradation: mechanisms, strategies and
2022年4月4日 · In addition to PROTAC, many different targeted protein degradation (TPD) strategies including, but not limited to, molecular glue, Lysosome-Targeting Chimaera (LYTAC), and Antibody-based PROTAC (AbTAC), are emerging.
Targeted Protein Degradation: Principles and Applications of the ...
Most cellular proteins are selectively degraded by the proteasome via ubiquitination. Moreover, the ubiquitin–proteasome system is a critical process for maintaining protein homeostasis.
Next steps for targeted protein degradation - Cell Press
2024年11月4日 · Targeted protein degradation (TPD) has greatly advanced as a therapeutic strategy in the past two decades, and we are on the cusp of rationally designed protein degraders reaching clinical approval.
Targeted protein degradation: A promise for undruggable proteins
2021年7月15日 · In this review, we discuss the progress and evolution of the TPD field, the breadth of the proteins targeted by PROTACs and the biological effects of their degradation.
New therapies on the horizon: Targeted protein degradation in ...
2024年9月19日 · Targeted protein degradation is a revolutionary small-molecule approach for neurologic diseases. Gregory et al. highlight cutting-edge advances in PROTAC degrader molecules, showcasing their ability to cross the blood-brain barrier and selectively degrade disease-causing proteins by design.