In the late 1950s and early 1960s, the use of thalidomide in 46 countries was prescribed to women who were pregnant or who subsequently became pregnant, and consequently resulted in the "biggest anthropogenic medical disaster ever," with more than 10,000 children born with a range of severe deformities, such as phocomelia, as well as thousands ...

Thalidomide was a widely used drug in the late 1950s and early 1960s for the treatment of nausea in pregnant women. It became apparent in the 1960s that thalidomide treatment resulted in severe birth defects in thousands of children.

Thalidomide is a known human teratogen and carries an extremely high risk of severe, life-threatening birth defects if administered or taken during pregnancy. [6] It causes skeletal deformities such as amelia (absence of legs and/or arms), absence of bones, and phocomelia (malformation of the limbs).

2011年4月19日 · Thalidomide was a widely used drug in the late 1950s and early 1960s for the treatment of nausea in pregnant women. It became apparent in the 1960s that thalidomide treatment resulted in severe birth defects in thousands of children.

2023年7月17日 · Thalidomide affected thousands of babies in Europe. Jennifer Vanderbes' book "Wonder Drug" unveils how the drug did damage in the U.S., too.

2018年5月14日 · Shortly after the teratogenic properties of thalidomide became known, astute physicians considered the drug as a possible cancer treatment. 9 They reasoned that a drug powerful enough to cause such severe defects in rapidly growing fetal tissues and organs would probably have similar effects against malignant tumors. 10 In fact, at least 3 ...

2020年12月15日 · In response to the thalidomide tragedy, governments mandated stricter regulations for approving new drugs. In this feature, we outline those important changes.

Sixty years ago (2 December 1961) the sedative drug thalidomide was withdrawn from use in the UK. After being on the market for five years as a treatment for morning sickness in pregnant women, it had finally been established that the medicine was responsible for babies being born with underdeveloped arms and legs and other malformations.

Tragically, a new generation of thalidomide damaged children has been identified in Brazil. Yet, how thalidomide caused its devastating effects in the forming embryo remains unclear. However, studies in the past few years have greatly enhanced our understanding of the molecular mechanisms the drug.

2011年4月19日 · It became apparent in the 1960s that thalidomide treatment resulted in severe birth defects in thousands of children. Though the use of thalidomide was banned in most countries at that time, thalidomide proved to be a useful treatment for …