Transplatin - Wikipedia
trans-Dichlorodiammineplatinum(II) is the trans isomer of the coordination complex with the formula trans-PtCl 2 (NH 3) 2, sometimes called transplatin. [1] It is a yellow solid with low solubility in water but good solubility in DMF .
Different Effects of Cisplatin and Transplatin on the Higher-Order ...
Despite the effectiveness of cisplatin as an anticancer agent, its trans-isomer, transplatin, is clinically ineffective. Although both isomers target nuclear DNA, there is a large difference in the magnitude of their biological effects.
Transplatin - an overview | ScienceDirect Topics
Transplatin (Fig. 6), the trans isomer of cisplatin, is inactive in cancer cells because of the kinetic instability that accelerates its deactivation and the limited ability to form intrastrand crosslinks with DNA. 104 Later, it was noted that the substitution of amines in transplatin to bulky heteroaromatic, iminoether, or asymmetric aliphatic ...
Transplatin - an overview | ScienceDirect Topics
Transplatin, the stereoisomer of cisplatin, is clinically ineffective. Although the mechanism of action of the antitumor drug cisplatin has yet to be totally elucidated, several results show that the activity of the drug is related to its binding to cellular DNA (Zamble & Lippard, 1999).
Transplatin - an overview | ScienceDirect Topics
Cisplatin (cis -diamminedichloroplatinum) has activity against various solid tumors and is frequently used in combination chemotherapy. Its toxicities include myelosuppression and renal dysfunction.
Metals in medicine: 5.5 Why is transplatin inactive? - OpenLearn
The lack of anticancer activity with transplatin is believed to be because transplatin lesions are more easily repaired than those of cisplatin, as they lead to more radical distortion of DNA.
transplatin (CHEBI:35852) - EMBL-EBI
transplatin: ChEBI ID CHEBI:35852: Definition A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a trans planar configuration around the central platinum ion.
Platinum-based drugs for cancer therapy and anti-tumor strategies
Pt-based nanodrugs, such as platinum nanoclusters, have novel anti-cancer mechanisms and great potential in tumor-targeted therapy and have shown promising results in clinical application. In this review, we systematically explored the development of first-line platinum chemotherapy drugs in the clinic and their anti-cancer mechanisms.
Molecular Mechanisms of Resistance and Toxicity Associated with ...
The chemical structures of cisplatin, transplatin, carboplatin, oxaliplatin, and satraplatin. In this review, we will focus on the most commonly used platinating agents - cisplatin, carboplatin, and oxaliplatin.
Trans-platinum complexes in cancer therapy - PubMed
It is widely accepted that transplatin inactivity stems from two major factors: i) the kinetic instability promoting its deactivation and ii) the formation of DNA adducts characterized by a regioselectivity and a stereochemistry different from those of cisplatin.