Th17 cells stimulate many cell types to recruit neutrophils to sites of infection, and mediate immune responses against extracellular bacteria and fungi. Tfh cells stimulate B cell maturation at germinal centers. Treg cells inhibit immune responses to maintain immune homeostasis.

2023年5月23日 · Here, we introduce the fundamental biology of TGF-β superfamily signaling, Treg cells, and Th17 cells and discuss in detail how the TGF-β superfamily contributes to Treg and Th17 cell...

Although Treg and Th17 cells have a completely different function in the immune responses, the differentiation of both cell subsets does need TGF-β. In this review, I will discuss the differentiation and relation of Tregs and Th17 cells, in particular Treg cell conversion to Th17 cells.

Regulatory T cells and T helper 17 cells are two recently described lymphocyte subsets with opposing actions. In this review, we discuss the mechanisms that promote development of these cells from...

2018年3月3日 · T helper type 17 (Th17) cells and pTreg cells, which share a common precursor cell (the naïve CD4 T cell), require a common tumor growth factor (TGF)-β signal for initial differentiation.

In this review, we discuss Treg and Th17 cell plasticity, its dynamic regulation by the microbiome, and highlight its impact on intestinal homeostasis and disease. Keywords: T-regulatory cells, T-helper 17 cells, intestinal homeostasis, gut microbiome, inflammatory bowel disease.

2020年12月15日 · Studies have shown that the imbalance between T helper 17 (Th17) and regulatory T (Treg) cells, which differentiate from CD4 + T cells, contributes to IBD. Th17 cells promote tissue inflammation, and Treg cells suppress autoimmunity in IBD. Therefore, Th17/Treg cell balance is crucial.

2018年3月21日 · Th17 cells are vital for host defense against pathogens but have also been implicated in causing autoimmune disorders and cancer, though their role in carcinogenesis is less well understood....

In the presence of IL-1β and IL-6 Tregs can acquire a Th17-like phenotype. These cells secrete IL-17 and express RORc, high levels of CCR6 and CD161 but can retain suppressive capacity and FoxP3 expression (Th17 Treg).

2018年3月3日 · Th17 cells stimulate many cell types to recruit neutrophils to sites of infection, and mediate immune responses against extracellular bacteria and fungi. Tfh cells stimulate B cell maturation at germinal centers. Treg cells inhibit immune responses to …